Sarcopenia is not associated with morbidity, mortality, or recurrence after esophagectomy for cancer.

Autor: Siegal SR; Oregon Health & Science University, Department of Surgery, 3181 SW Sam Jackson Park Rd, Mail Code L223, Portland, OR 97239, USA. Electronic address: siegal@ohsu.edu., Dolan JP; Oregon Health & Science University, Department of Surgery, 3181 SW Sam Jackson Park Rd, Mail Code L223, Portland, OR 97239, USA. Electronic address: dolanj@ohsu.edu., Dewey EN; Oregon Health & Science University, Department of Surgery, 3181 SW Sam Jackson Park Rd, Mail Code L223, Portland, OR 97239, USA. Electronic address: deweye@ohsu.edu., Guimaraes AR; Oregon Health & Science University, Department of Diagnostic Radiology, 3181 SW Sam Jackson Park Road, Mail Code 340, Portland, OR 97239, USA. Electronic address: guimaraa@ohsu.edu., Tieu BH; Oregon Health & Science University, Department of Surgery, 3181 SW Sam Jackson Park Rd, Mail Code L223, Portland, OR 97239, USA. Electronic address: tieub@ohsu.edu., Schipper PH; Oregon Health & Science University, Department of Surgery, 3181 SW Sam Jackson Park Rd, Mail Code L223, Portland, OR 97239, USA. Electronic address: schippep@ohsu.edu., Hunter JG; Oregon Health & Science University, Department of Surgery, 3181 SW Sam Jackson Park Rd, Mail Code L223, Portland, OR 97239, USA. Electronic address: hunter@ohsu.edu.
Jazyk: angličtina
Zdroj: American journal of surgery [Am J Surg] 2018 May; Vol. 215 (5), pp. 813-817. Date of Electronic Publication: 2018 Jan 04.
DOI: 10.1016/j.amjsurg.2017.12.017
Abstrakt: Background: Sarcopenia is associated with increased morbidity and mortality in hepatic, pancreatic and colorectal cancer. We examined the effect of sarcopenia on morbidity, mortality, and recurrence after resection for esophageal cancer.
Methods: Retrospective review of consecutive esophagectomies from 2010 to 2015. Computed tomography studies were analyzed for sarcopenia. Morbidity was analyzed using Fischer's test and survival data with Kaplan Meier curves.
Results: The sarcopenic group (n = 127) had lower BMI, later stage disease, and higher incidence of neoadjuvant radiation than those without sarcopenia (n = 46). There were no differences in morbidity or mortality between the groups (p = .75 and p = .31, respectively). Mean length of stay was similar (p = .70). Disease free and overall survival were similar (p = .20 and p = .39, respectively).
Conclusion: There is no association between sarcopenia and increased morbidity, mortality and disease-free survival in patients undergoing esophagectomy for cancer. Sarcopenia in esophageal cancer may not portend worse outcomes that have been reported in other solid tumors.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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