Estrogens and their receptors in the medial amygdala rapidly facilitate social recognition in female mice.

Autor: Lymer JM; Department of Psychology and Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada., Sheppard PAS; Department of Psychology and Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada., Kuun T; Department of Psychology and Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada., Blackman A; Department of Psychology and Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada., Jani N; Department of Psychology and Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada., Mahbub S; Department of Psychology and Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada., Choleris E; Department of Psychology and Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada. Electronic address: echoleri@uoguelph.ca.
Jazyk: angličtina
Zdroj: Psychoneuroendocrinology [Psychoneuroendocrinology] 2018 Mar; Vol. 89, pp. 30-38. Date of Electronic Publication: 2017 Dec 28.
DOI: 10.1016/j.psyneuen.2017.12.021
Abstrakt: Estrogens have been shown to rapidly (within 1 h) affect learning and memory processes, including social recognition. Both systemic and hippocampal administration of 17β-estradiol facilitate social recognition in female mice within 40 min of administration. These effects were likely mediated by estrogen receptor (ER) α and the G-protein coupled estrogen receptor (GPER), as administration of the respective receptor agonists (PPT and G-1) also facilitated social recognition on a rapid time scale. The medial amygdala has been shown to be necessary for social recognition and long-term manipulations in rats have implicated medial amygdalar ERα. As such, our objective was to investigate whether estrogens and different ERs within the medial amygdala play a role in the rapid facilitation of social recognition in female mice. 17β-estradiol, G-1, PPT, or ERβ agonist DPN was infused directly into the medial amygdala of ovariectomized female mice. Mice were then tested in a social recognition paradigm, which was completed within 40 min, thus allowing the assessment of rapid effects of treatments. 17β-estradiol (10, 25, 50, 100 nM), PPT (300 nM), DPN (150 nM), and G-1 (50 nM) each rapidly facilitated social recognition. Therefore, estrogens in the medial amygdala rapidly facilitate social recognition in female mice, and the three main estrogen receptors: ERα, ERβ, and the GPER all are involved in these effects. This research adds to a network of brain regions, including the medial amygdala and the dorsal hippocampus, that are involved in mediating the rapid estrogenic facilitation of social recognition in female mice.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: