Higher schizotypy predicts better metabolic profile in unaffected siblings of patients with schizophrenia.

Autor: Atbasoglu EC; Faculty of Medicine, Department of Psychiatry, Ankara University, Ankara, Turkey. atbasoglu@gmail.com., Gumus-Akay G; Brain Research Center, Ankara University, Ankara, Turkey., Guloksuz S; Maastricht University Medical Centre, Maastricht, Netherlands., Saka MC; Faculty of Medicine, Department of Psychiatry, Ankara University, Ankara, Turkey., Ucok A; Istanbul Faculty of Medicine, Department of Psychiatry, Istanbul University, Istanbul, Turkey., Alptekin K; Faculty of Medicine, Department of Psychiatry, Dokuz Eylul University, İzmir, Turkey., Gullu S; Faculty of Medicine, Department of Endocrinology and Metabolic Diseases, Ankara University, Ankara, Turkey., van Os J; Maastricht University Medical Centre, Maastricht, Netherlands.; Brain Centre Rudolf Magnus, Utrecht University Medical Centre, Utrecht, Netherlands.; King's College London, Department of Psychosis Studies, Institute of Psychiatry, London, UK.
Jazyk: angličtina
Zdroj: Psychopharmacology [Psychopharmacology (Berl)] 2018 Apr; Vol. 235 (4), pp. 1029-1039. Date of Electronic Publication: 2018 Jan 06.
DOI: 10.1007/s00213-017-4818-z
Abstrakt: Rationale: Type 2 diabetes (T2D) is more frequent in schizophrenia (Sz) than in the general population. This association is partly accounted for by shared susceptibility genetic variants.
Objective: We tested the hypotheses that a genetic predisposition to Sz would be associated with higher likelihood of insulin resistance (IR), and that IR would be predicted by subthreshold psychosis phenotypes.
Methods: Unaffected siblings of Sz patients (n = 101) were compared with a nonclinical sample (n = 305) in terms of IR, schizotypy (SzTy), and a behavioural experiment of "jumping to conclusions". The measures, respectively, were the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), Structured Interview for Schizotypy-Revised (SIS-R), and the Beads Task (BT). The likelihood of IR was examined in multiple regression models that included sociodemographic, metabolic, and cognitive parameters alongside group status, SIS-R scores, and BT performance.
Results: Insulin resistance was less frequent in siblings (31.7%) compared to controls (43.3%) (p < 0.05), and negatively associated with SzTy, as compared among the tertile groups for the latter (p < 0.001). The regression model that examined all relevant parameters included the tSzTy tertiles, TG and HDL-C levels, and BMI, as significant predictors of IR. Lack of IR was predicted by the highest as compared to the lowest SzTy tertile [OR (95%CI): 0.43 (0.21-0.85), p = 0.015].
Conclusion: Higher dopaminergic activity may contribute to both schizotypal features and a favourable metabolic profile in the same individual. This is compatible with dopamine's regulatory role in glucose metabolism via indirect central actions and a direct action on pancreatic insulin secretion. The relationship between dopaminergic activity and metabolic profile in Sz must be examined in longitudinal studies with younger unaffected siblings.
Databáze: MEDLINE
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