Exploring the Chemical Diversity of Algerian Plants: Three New Pentacyclic Triterpenoids from Launaea acanthoclada Roots.

Autor: Zergainoh N; National Research Council (CNR), Institute of Biomolecular Chemistry (ICB), Via Campi Flegrei, 34, 80078 Pozzuoli (Naples), Italy. n.zergainoh@icb.cnr.it.; Laboratory of Chemistry and Environmental Chemistry (L.C.C.E), Department of Chemistry, Faculty of Sciences of the Matter, University of Batna 1, 05000 Batna, Algeria. n.zergainoh@icb.cnr.it., Ciavatta ML; National Research Council (CNR), Institute of Biomolecular Chemistry (ICB), Via Campi Flegrei, 34, 80078 Pozzuoli (Naples), Italy. lciavatta@icb.cnr.it., Carbone M; National Research Council (CNR), Institute of Biomolecular Chemistry (ICB), Via Campi Flegrei, 34, 80078 Pozzuoli (Naples), Italy. mcarbone@icb.cnr.it., Bitam F; Department of Pharmacy, University of Batna 2, Faculty of Medicine, 05000 Batna, Algeria. fatoma597@gmail.com., Aberkane MC; Laboratory of Chemistry and Environmental Chemistry (L.C.C.E), Department of Chemistry, Faculty of Sciences of the Matter, University of Batna 1, 05000 Batna, Algeria. aberkanemc@yahoo.fr., Gavagnin M; National Research Council (CNR), Institute of Biomolecular Chemistry (ICB), Via Campi Flegrei, 34, 80078 Pozzuoli (Naples), Italy. mgavagnin@icb.cnr.it.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2017 Dec 30; Vol. 23 (1). Date of Electronic Publication: 2017 Dec 30.
DOI: 10.3390/molecules23010080
Abstrakt: The chemical study of Launaea acanthoclada from South-East Algeria led to the isolation of twelve oxygenated terpenoid compounds, including three new pentacyclic triterpenoids 1 - 3 with either lupane or ursane rearranged skeletons. The structure and the stereochemistry of these compounds were established by spectroscopic methods, including NMR techniques. The chemical pattern of L. acanthoclada is in accordance with the triterpenoid scenario of the genus Launaea embracing to date lupane, oleane, ursane and taraxastane skeletons. However, the carbon frameworks exhibited by new compounds 1 - 3 have never been reported from Launaea species.
Competing Interests: The authors declare no conflicts of interest.
Databáze: MEDLINE
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