The inhibitory effect of dinitrosyl iron complexes (NO donors) on myeloperoxidase activity.

Autor:	Akentieva NP; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia. na_aken@icp.ac.ru., Sanina NA; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia., Gizatullin AR; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia., Shmatko NY; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia., Goryachev NS; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia., Shkondina NI; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia., Prikhodchenko TR; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia., Aldoshin SM; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow oblast, Russia.
Jazyk:	angličtina
Zdroj:	Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2017 Nov; Vol. 477 (1), pp. 389-393. Date of Electronic Publication: 2018 Jan 03.
DOI:	10.1134/S1607672917060126
Abstrakt:	The effect of synthetic analogues of dinitrosyl mononuclear iron complexes (DNICs) with functional sulfur-containing ligands (NO donors) on the activity of myeloperoxidase (MPO) was studied, and their efficiency was evaluated. It was shown that the enzyme MPO is the molecular target of DNICs. It was found that six DNICs inhibited the activity of MPO and one compound potentiated it. The evaluation of their efficiency showed that two DNICs effectively inhibited the activity of MPO by 50% at IC 50 = 2 × 10 -4 M and IC 50 = 5 × 10 -7 M.
Databáze:	MEDLINE
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