| Autor: |
Ferreira MDF; Hospital for Small Animals, The Royal (Dick) School of Veterinary Studies, The University of Edinburgh, UK., Aylor AEA; Hospital for Small Animals, The Royal (Dick) School of Veterinary Studies, The University of Edinburgh, UK., Mellanby RJ; Hospital for Small Animals, The Royal (Dick) School of Veterinary Studies, The University of Edinburgh, UK., Campbell SM; Hospital for Small Animals, The Royal (Dick) School of Veterinary Studies, The University of Edinburgh, UK., Gow AG; Hospital for Small Animals, The Royal (Dick) School of Veterinary Studies, The University of Edinburgh, UK. |
| Jazyk: |
angličtina |
| Zdroj: |
Open veterinary journal [Open Vet J] 2017; Vol. 7 (4), pp. 360-366. Date of Electronic Publication: 2017 Dec 13. |
| DOI: |
10.4314/ovj.v7i4.12 |
| Abstrakt: |
Lethargy is a frequent and important clinical feature of anaemia; however, it does not absolutely correlate with the severity of anaemia. Manganese is efficiently absorbed through the gastrointestinal tract via divalent metal transporter 1 (DMT1), which is also responsible for iron transport. DMT1 is upregulated in iron deficiency (ID). Increased manganese concentrations are reported in ID anaemia (IDA) in various species. Manganese is neurotoxic and therefore may contribute to lethargy observed in some anaemic patients. In addition, anaemia and ID are common in human inflammatory bowel disease. Little is known about how anaemia influences manganese metabolism in veterinary patients and how common is anaemia in dogs with chronic enteropathy (CE). If elevated manganese concentrations are found, then potentially neurotoxicity may be contributing to morbidity in these cases. The objectives of this study were to investigate the hypothesis that whole blood manganese concentrations would be increased in dogs with anaemia, particularly in dogs with confirmed IDA, and that anaemia would be common in canine CE. Medical records from 2012-2016 were reviewed for dogs with CE that were anaemic, as well as dogs with confirmed IDA, where a sample suitable for manganese analysis was held in an archive. Manganese concentration was measured in whole blood from: 11 anaemic dogs with CE, 6 dogs with IDA, 9 non-anaemic ill controls, and 12 healthy controls. Mann-Whitney U and Kruskal-Wallis tests with post-test Dunn's multiple comparisons tests were performed, with P<0.05 considered significant. The prevalence of anaemia in canine CE was 20.6% (33/160). Manganese concentrations were significantly different between all groups ( P =0.0001) and higher in non-anaemic than anaemic dogs ( P =0.0078). Manganese concentrations were also higher in healthy compared to ill controls ( P <0.0001), anaemic dogs with CE ( P =0.0056) and to dogs with IDA ( P =0.0001). No differences were observed between anaemic dogs with CE, IDA and ill controls. Although anaemia was frequently observed in canine CE, the hypothesis that dogs with anaemia would have increased manganese concentrations, possibly contributing to a lethargic state was not supported. Further research is warranted to understand the influence of anaemia on whole blood manganese. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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