Recent Advances in Organocatalyzed Domino C-C Bond-Forming Reactions.

Autor: Evans CS; Department of Chemistry and Biochemistry, Berry College, P.O. Box 495016, Mt. Berry, GA 30149, USA. cleo.evans@vikings.berry.edu., Davis LO; Department of Chemistry and Biochemistry, Berry College, P.O. Box 495016, Mt. Berry, GA 30149, USA. ldavis@berry.edu.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2017 Dec 23; Vol. 23 (1). Date of Electronic Publication: 2017 Dec 23.
DOI: 10.3390/molecules23010033
Abstrakt: Reactions that form a C-C bond make up a foundational pillar of synthetic organic chemistry. In addition, organocatalysis has emerged as an easy, environmentally-friendly way to promote this type of bond formation. Since around 2000, organocatalysts have been used in a variety of C-C bond-forming reactions including Michael and aldol additions, Mannich-type reactions, and Diels-Alder reactions, to name a few. Many of these methodologies have been refined and further developed to include cascade and domino processes. This review will focus on recent advances in this area with an emphasis on methodologies having applications in the synthesis of biologically-significant compounds.
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE
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