Emerging roles of CST in maintaining genome stability and human disease.

Autor:	Stewart JA; Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA, jason.stewart@sc.edu., Wang Y; Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA., Ackerson SM; Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA., Schuck PL; Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA.
Jazyk:	angličtina
Zdroj:	Frontiers in bioscience (Landmark edition) [Front Biosci (Landmark Ed)] 2018 Mar 01; Vol. 23 (8), pp. 1564-1586. Date of Electronic Publication: 2018 Mar 01.
DOI:	10.2741/4661
Abstrakt:	The human CTC1-STN1-TEN1 (CST) complex is a single-stranded DNA binding protein that shares homology with RPA and interacts with DNA polymerase alpha/primase. CST complexes are conserved from yeasts to humans and function in telomere maintenance. A common role of CST across species is in the regulation of telomere extension by telomerase and C-strand fill-in synthesis. However, recent studies also indicate that CST promotes telomere duplex replication as well the rescue of stalled DNA replication at non-telomeric sites. Furthermore, CST dysfunction and mutation is associated with several genetic diseases and cancers. In this review, we will summarize what is known about CST with a particular focus on the emerging roles of CST in DNA replication and human disease.
Databáze:	MEDLINE
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