Reciprocal Regulation of the TOR Kinase and ABA Receptor Balances Plant Growth and Stress Response.

Autor:	Wang P; Shanghai Center for Plant Stress Biology, CAS Center of Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 200032, China; Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907, USA., Zhao Y; Shanghai Center for Plant Stress Biology, CAS Center of Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 200032, China., Li Z; Shanghai Center for Plant Stress Biology, CAS Center of Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 200032, China., Hsu CC; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA., Liu X; Shanghai Center for Plant Stress Biology, CAS Center of Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 200032, China., Fu L; Shanghai Center for Plant Stress Biology, CAS Center of Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 200032, China., Hou YJ; Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907, USA., Du Y; Shanghai Center for Plant Stress Biology, CAS Center of Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 200032, China., Xie S; Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907, USA., Zhang C; Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907, USA., Gao J; Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907, USA., Cao M; Shanghai Center for Plant Stress Biology, CAS Center of Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 200032, China., Huang X; Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907, USA., Zhu Y; Shanghai Center for Plant Stress Biology, CAS Center of Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 200032, China; Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907, USA., Tang K; Shanghai Center for Plant Stress Biology, CAS Center of Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 200032, China; Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907, USA., Wang X; Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907, USA., Tao WA; Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA., Xiong Y; Shanghai Center for Plant Stress Biology, CAS Center of Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 200032, China. Electronic address: yanxiong@sibs.ac.cn., Zhu JK; Shanghai Center for Plant Stress Biology, CAS Center of Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 200032, China; Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907, USA. Electronic address: jkzhu@sibs.ac.cn.
Jazyk:	angličtina
Zdroj:	Molecular cell [Mol Cell] 2018 Jan 04; Vol. 69 (1), pp. 100-112.e6. Date of Electronic Publication: 2017 Dec 28.
DOI:	10.1016/j.molcel.2017.12.002
Abstrakt:	As sessile organisms, plants must adapt to variations in the environment. Environmental stress triggers various responses, including growth inhibition, mediated by the plant hormone abscisic acid (ABA). The mechanisms that integrate stress responses with growth are poorly understood. Here, we discovered that the Target of Rapamycin (TOR) kinase phosphorylates PYL ABA receptors at a conserved serine residue to prevent activation of the stress response in unstressed plants. This phosphorylation disrupts PYL association with ABA and with PP2C phosphatase effectors, leading to inactivation of SnRK2 kinases. Under stress, ABA-activated SnRK2s phosphorylate Raptor, a component of the TOR complex, triggering TOR complex dissociation and inhibition. Thus, TOR signaling represses ABA signaling and stress responses in unstressed conditions, whereas ABA signaling represses TOR signaling and growth during times of stress. Plants utilize this conserved phospho-regulatory feedback mechanism to optimize the balance of growth and stress responses. (Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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