| Autor: |
Sobus JR; U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, 109 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA. sobus.jon@epa.gov., Wambaugh JF; U.S. Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, 109 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA., Isaacs KK; U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, 109 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA., Williams AJ; U.S. Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, 109 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA., McEachran AD; Oak Ridge Institute for Science and Education (ORISE) Participant, 109 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA., Richard AM; U.S. Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, 109 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA., Grulke CM; U.S. Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, 109 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA., Ulrich EM; U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, 109 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA., Rager JE; Oak Ridge Institute for Science and Education (ORISE) Participant, 109 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA.; ToxStrategies, Inc., 9390 Research Blvd., Suite 100, Austin, TX, 78759, USA., Strynar MJ; U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, 109 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA., Newton SR; U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, 109 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA. |
| Abstrakt: |
Tens-of-thousands of chemicals are registered in the U.S. for use in countless processes and products. Recent evidence suggests that many of these chemicals are measureable in environmental and/or biological systems, indicating the potential for widespread exposures. Traditional public health research tools, including in vivo studies and targeted analytical chemistry methods, have been unable to meet the needs of screening programs designed to evaluate chemical safety. As such, new tools have been developed to enable rapid assessment of potentially harmful chemical exposures and their attendant biological responses. One group of tools, known as "non-targeted analysis" (NTA) methods, allows the rapid characterization of thousands of never-before-studied compounds in a wide variety of environmental, residential, and biological media. This article discusses current applications of NTA methods, challenges to their effective use in chemical screening studies, and ways in which shared resources (e.g., chemical standards, databases, model predictions, and media measurements) can advance their use in risk-based chemical prioritization. A brief review is provided of resources and projects within EPA's Office of Research and Development (ORD) that provide benefit to, and receive benefits from, NTA research endeavors. A summary of EPA's Non-Targeted Analysis Collaborative Trial (ENTACT) is also given, which makes direct use of ORD resources to benefit the global NTA research community. Finally, a research framework is described that shows how NTA methods will bridge chemical prioritization efforts within ORD. This framework exists as a guide for institutions seeking to understand the complexity of chemical exposures, and the impact of these exposures on living systems. |
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