Autoimmune hepatitis association with single nucleotide polymorphism of interleukin-2, but not interferon-gamma.

Autor: Yousefi A; Department of Gastroenterology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran., Mahmoudi E; Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran., Baradaran Noveiry B; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Baltimore, MD, USA; Department of Gastroenterology, Johns Hopkins Hospital, Baltimore, MD, USA., Zare Bidoki A; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Sadr M; Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran., Motamed F; Department of Gastroenterology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran., Najafi M; Department of Gastroenterology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran., Farahmand F; Department of Gastroenterology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran., Khodadad A; Department of Gastroenterology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran., Fallahi GH; Department of Gastroenterology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran., Rezaei N; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Research Center for Immunodeficiencies, Children's Medical Center Hospital, Tehran University of Medical Sciences, Dr Qarib St, Keshavarz Blvd, 14194 Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address: rezaei_nima@tums.ac.ir.
Jazyk: angličtina
Zdroj: Clinics and research in hepatology and gastroenterology [Clin Res Hepatol Gastroenterol] 2018 Apr; Vol. 42 (2), pp. 134-138. Date of Electronic Publication: 2017 Dec 26.
DOI: 10.1016/j.clinre.2017.06.005
Abstrakt: Background: Autoimmune hepatitis (AIH) is a chronic inflammation in hepatocellular tissues associated with circulating autoantibodies. Imbalance in T-cells population and dysregulation in several cytokine profiles has been implicated in pathogenesis of AIH. This study was performed to assess potential association of AIH with interleukin-2 (IL-2) and interferon-gamma (IFN-γ) genes single nucleotide polymorphisms (SNPs).
Methods: Fifty-six patients with AIH and 139 healthy individuals were enrolled in this study. IL-2 and IFN-γ typing was performed, using polymerase chain reaction with sequence-specific primers (PCR-SSP) assay. The frequencies of alleles, genotypes and haplotypes in AIH patients were compared to healthy controls.
Results: IL-2 T allele at position +166 (rs2069763) showed significant higher frequency in AIH group (36%), compared to the controls (21%) (OR=2.06; 95% CI, 1.24-3.43, P-value<0.01). The frequency of IL-2 TT genotype at +166 position was also associated with AIH (OR=18.68, 95% CI 3.74-126.04, P-value<0.01). G/T alleles of IL-2 at -330 (rs2069762) and A/T alleles on UTR +5644 position at IFN-γ and their subsequent haplotypes, did not show significant association with AIH.
Conclusions: This study identified IL-2T allele at +166 position and TT genotype as susceptibility gene in AIH which would provide better understandings into the mechanisms of AIH and potential immune modulation therapies.
(Copyright © 2017 Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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