[Pathogenetic and Prognostic Role of Growth Factors in the Development of Chronic Heart Failure].

Autor:	Teplyakov AT; Federal State Budgetary Science Institution 'Tomsk Research Institute of Cardiology of the Siberian Branch of the Russian Academy of Science'., Berezikova EN; State Budgetary Educational Institution of Higher Professional Education, 'Novosibirsk State Medical University' of the Ministry of Health of the Russian Federation., Shilov SN; State Budgetary Educational Institution of Higher Professional Education, 'Novosibirsk State Medical University' of the Ministry of Health of the Russian Federation., Efremova AV; State Budgetary Educational Institution of Higher Professional Education, 'Novosibirsk State Medical University' of the Ministry of Health of the Russian Federation., Pustovetova MG; State Budgetary Educational Institution of Higher Professional Education, 'Novosibirsk State Medical University' of the Ministry of Health of the Russian Federation., Popova AA; State Budgetary Educational Institution of Higher Professional Education, 'Novosibirsk State Medical University' of the Ministry of Health of the Russian Federation., Grakova EV; Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences., Torim YY; Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences., Safronov ID; State Budgetary Educational Institution of Higher Professional Education, 'Novosibirsk State Medical University' of the Ministry of Health of the Russian Federation., Andriyanova AV; Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences.
Jazyk:	ruština
Zdroj:	Kardiologiia [Kardiologiia] 2017 Oct; Vol. 57 (10), pp. 20-28.
DOI:	10.18087/cardio.2017.10.10039
Abstrakt:	Aim: To study the role of growth factors ((vascular endothelial growth factor (VEGF), platelet derived growth factor AB (PDGF-AB) and basic fibroblast growth factor (FGF-basic)) in the development and progression of chronic heart failure (CHF) in patients with ishcemic heart disease (IHD). Materials and Methods: We included in this study 94 patients with CHF. The control group comprised 32 persons. Blood serum levels of growth factors were determined at baseline and after 12 months of observation by enzyme-linked immunosorbent assay. Results: VEGF, PDGF-AB and FGF-basic play an important role in the pathogenesis and progression of heart failure in patients with IHD, determining the increased risk of adverse cardiovascular events in this pathology. Serum activity of growth factors characterizes the severity and course of CHF: with disease progression levels of VEGF and FGF-basic decrease and PDGF-AB concentration increases. Initial low level of VEGF expression regardless of the sex of the patient's sex, significantly low level of FGF-basic and significantly high PDGF-AB in men characterizes unfavorable course of CHF. Conclusion: A correlation has been established between blood serum levels of VEGF, PDGF-AB and FGF-basic and severity and course of CHF.
Databáze:	MEDLINE
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