Rattle-type Au@Cu 2-x S hollow mesoporous nanocrystals with enhanced photothermal efficiency for intracellular oncogenic microRNA detection and chemo-photothermal therapy.

Autor: Cao Y; Research Center for Bioengineering and Sensing Technology, Beijing Key Laboratory for Bioengineering and Sensing Technology, School of Chemistry & Biological Engineering University of Science & Technology Beijing, Beijing 100083, PR China., Li S; School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore., Chen C; School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore., Wang D; Research Center for Bioengineering and Sensing Technology, Beijing Key Laboratory for Bioengineering and Sensing Technology, School of Chemistry & Biological Engineering University of Science & Technology Beijing, Beijing 100083, PR China., Wu T; Research Center for Bioengineering and Sensing Technology, Beijing Key Laboratory for Bioengineering and Sensing Technology, School of Chemistry & Biological Engineering University of Science & Technology Beijing, Beijing 100083, PR China., Dong H; Research Center for Bioengineering and Sensing Technology, Beijing Key Laboratory for Bioengineering and Sensing Technology, School of Chemistry & Biological Engineering University of Science & Technology Beijing, Beijing 100083, PR China. Electronic address: hfdong@ustb.edu.cn., Zhang X; Research Center for Bioengineering and Sensing Technology, Beijing Key Laboratory for Bioengineering and Sensing Technology, School of Chemistry & Biological Engineering University of Science & Technology Beijing, Beijing 100083, PR China. Electronic address: zhangxueji@ustb.edu.cn.
Jazyk: angličtina
Zdroj: Biomaterials [Biomaterials] 2018 Mar; Vol. 158, pp. 23-33. Date of Electronic Publication: 2017 Dec 13.
DOI: 10.1016/j.biomaterials.2017.12.009
Abstrakt: The coupling of the localized surface plasma resonance (LSPR) between noble metals of Au, Ag and Cu and semiconductors of Cu 2-x E (E = S, Se, Te) opens new regime to design photothermal (PT) agents with enhanced PT conversion efficiency. However, it is rarely explored on fabricating of engineered dual plasmonic hybrid nanosystem for combinatory therapeutic-diagnostic applications. Herein, rattle-type Au@Cu 2-x S hollow mesoporous nanoparitcles with advanced PT conversion efficiency are designed for cellular vehicles and chemo-photothermal synergistic therapy platform. The LSPR coupling between the Au core and Cu 2-x S shell are investigated experimentally and theoretically to generate a PT conversion efficiency high to 35.2% and enhanced by 11.3% than that of Cu 2-x S. By conjugating microRNA (miRNA) gene probe on the surface, it can realize the intracellular oncogenic miRNA detection. After loading of anticancer drug doxorubicin into the cavity of the Au@Cu 2-x S, the antitumor therapy efficacy is greatly enhanced in vitro and in vivo due to the NIR photoactivation chemo- and photothermal synergistic therapy. The rattle-type metal-semiconductor hollow mesoporous nanostructure with efficient LSPR coupling and high cargo loading capability will be beneficial to future design of LSPR-based photothermal agents for a broad range of biomedical application.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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