Branching tryptamines as a tool to tune their antiproliferative activity.

Autor: Salikov RF; N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, 119991 Moscow, Russian Federation., Trainov KP; N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, 119991 Moscow, Russian Federation., Belousova IK; Moscow Chemical Lyceum, 4 Tamozhennyj Proezd, 111033 Moscow, Russian Federation., Belyy AY; N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, 119991 Moscow, Russian Federation., Fatkullina US; Institute of Biochemistry and Genetics Ufa Science Centre of the Russian Academy of Sciences, pr. Oktyabrya 71, 450054 Ufa, Russian Federation., Mulyukova RV; Institute of Biochemistry and Genetics Ufa Science Centre of the Russian Academy of Sciences, pr. Oktyabrya 71, 450054 Ufa, Russian Federation., Zainullina LF; Institute of Biochemistry and Genetics Ufa Science Centre of the Russian Academy of Sciences, pr. Oktyabrya 71, 450054 Ufa, Russian Federation; Department of Pharmacogenetics, Zakusov Institute of Pharmacology, 8 Baltiyskaya ul., 125315 Moscow, Russian Federation., Vakhitova YV; Institute of Biochemistry and Genetics Ufa Science Centre of the Russian Academy of Sciences, pr. Oktyabrya 71, 450054 Ufa, Russian Federation; Department of Pharmacogenetics, Zakusov Institute of Pharmacology, 8 Baltiyskaya ul., 125315 Moscow, Russian Federation., Tomilov YV; N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prospect, 119991 Moscow, Russian Federation. Electronic address: tom@ioc.ac.ru.
Jazyk: angličtina
Zdroj: European journal of medicinal chemistry [Eur J Med Chem] 2018 Jan 20; Vol. 144, pp. 211-217. Date of Electronic Publication: 2017 Dec 09.
DOI: 10.1016/j.ejmech.2017.12.028
Abstrakt: The influence of a series of tryptamine derivatives on the viability of normal (HEK293) and tumor (HepG2, Jurkat and SH-SY5Y) cells has been evaluated. All tryptamines tested were three different substitution types: C- and N-branching, and indole benzylation. All the derivations enhance the activity of compounds separately, although the effects of different substitutions were not additive. Thus, combinations of C- and N-branchings as well as C-branching and indole benzylation gave little or no increase in activity.
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Databáze: MEDLINE
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