Lipid-lowering and antiatherogenic effects of Vitex megapotamica (Spreng.) Moldenke in a mice experimental model.

Autor: Pires VA; Department of Pharmacology, Biological Sciences Center, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil; Prati-Donaduzzi Pharmaceutical Co., Toledo, PR, Brazil., Cardozo-Junior EL; Institute of Biological, Medical and Health Sciences, Universidade Paranaense, Toledo, PR, Brazil. Electronic address: euclideslc@unipar.br., Ortmann CF; Department of Pharmaceutical Sciences, Health Sciences Center, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil., Maraschin JC; Institute of Biological, Medical and Health Sciences, Universidade Paranaense, Toledo, PR, Brazil., Favreto WAJ; Prati-Donaduzzi Pharmaceutical Co., Toledo, PR, Brazil., Donaduzzi CM; Prati-Donaduzzi Pharmaceutical Co., Toledo, PR, Brazil., Reginatto FH; Department of Pharmaceutical Sciences, Health Sciences Center, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil., Assreuy J; Department of Pharmacology, Biological Sciences Center, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
Jazyk: angličtina
Zdroj: Journal of ethnopharmacology [J Ethnopharmacol] 2018 Apr 06; Vol. 215, pp. 14-20. Date of Electronic Publication: 2017 Dec 20.
DOI: 10.1016/j.jep.2017.12.030
Abstrakt: Ethnopharmacological Relevance: Vitex megapotamica (Spreng.) Moldenke is a deciduous tree, native of South America. Its leaves are traditionally used to treat cardiovascular diseases. This activity is related to the presence of flavonoids, the major compounds of the crude extract.
Aim of the Study: This study investigated the effects of the oral administration of crude extract and standardized fractions from V. megapotamica leaves on lipid profile and on the formation of atherosclerotic plaque in C57BL/6 LDLr-KO mice treated with high-fat diet (HFD).
Materials and Methods: Male C57BL/6 LDLr-KO mice were fed with HFD (cholesterol, 1.25%) for 30 days. They were treated with hydroethanolic extract (500 or 1000mg/kg/day) or fractions (125 or 250mg/kg/day). After 30 days of treatment, it was evaluated the serum lipid profile, atherogenic index, and atherosclerotic plaque.
Results: All doses of the hydroethanolic extract reduced significantly the levels of total cholesterol, triglycerides, LDL-c and the atherogenic index. The n-butanolic fraction also reduced significantly the levels of total cholesterol, triglycerides, LDL-c and the atherogenic index, at all doses, with exception for the triglycerides, which only the lower dose was effective. The residual fraction reduced significantly the levels of total cholesterol, LDL-c and the atherogenic index, at all doses, with exception for the atherogenic index, which only the higher dose was effective. The atherosclerotic plaque formation was impaired only by the lower dose of the hydroethanolic extract.
Conclusions: Overall, our data suggest that V. megapotamica has potential for the treatment of dyslipidemias.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: