High-Intensity Exercise Acutely Increases Substantia Nigra and Prefrontal Brain Activity in Parkinson's Disease.

Autor:	Kelly NA; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA.; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Wood KH; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.; Department Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Allendorfer JB; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.; Department Neurology, University of Alabama at Birmingham, Birmingham, AL, USA., Ford MP; Department of Physical Therapy, Samford University, Birmingham, AL, USA., Bickel CS; Department of Physical Therapy, Samford University, Birmingham, AL, USA., Marstrander J; Department of Engineering, University of Alabama at Birmingham, Birmingham, AL, USA., Amara AW; Department of Physical Therapy, University of Alabama, Birmingham, AL, USA., Anthony T; Department of Engineering, University of Alabama at Birmingham, Birmingham, AL, USA., Bamman MM; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA.; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.; Geriatric Research, Education, and Clinical Center, Birmingham VA Medical Center, Birmingham, AL, USA., Skidmore FM; UAB Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.; Department Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Jazyk:	angličtina
Zdroj:	Medical science monitor : international medical journal of experimental and clinical research [Med Sci Monit] 2017 Dec 23; Vol. 23, pp. 6064-6071. Date of Electronic Publication: 2017 Dec 23.
DOI:	10.12659/msm.906179
Abstrakt:	BACKGROUND Pathologic alterations in resting-state brain activity patterns exist among individuals with Parkinson's disease (PD). Since physical exercise alters resting-state brain activity in non-PD populations and improves PD symptoms, we assessed the acute effect of exercise on resting-state brain activity in exercise-trained individuals with PD. MATERIAL AND METHODS Resting-state functional magnetic resonance imaging (fMRI) was collected twice for 17 PD participants at the conclusion of an exercise intervention. The acute effect of exercise was examined for PD participants using the amplitude of low frequency fluctuation (ALFF) before and after a single bout of exercise. Correlations of clinical variables (i.e., PDQ-39 quality of life and MDS-UPDRS) with ALFF values were examined for the exercise-trained PD participants. RESULTS An effect of acute exercise was observed as an increased ALFF signal within the right ventromedial prefrontal cortex (PFC), left ventrolateral PFC, and bilaterally within the substantia nigra (SN). Quality of life was positively correlated with ALFF values within the vmPFC and vlPFC. CONCLUSIONS Given the role of the SN and PFC in motor and non-motor symptoms in PD, the acute increases in brain activity within these regions, if repeated frequently over time (i.e., exercise training), may serve as a potential mechanism underlying exercise-induced PD-specific clinical benefits.
Databáze:	MEDLINE
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