Opsin3-A Link to Visible Light-Induced Skin Pigmentation.
| Autor: | Setty SR; Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India. Electronic address: subba@iisc.ac.in. |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of investigative dermatology [J Invest Dermatol] 2018 Jan; Vol. 138 (1), pp. 13-15. |
| DOI: | 10.1016/j.jid.2017.09.025 |
| Abstrakt: | Skin pigmentation is primarily dependent on melanogenesis, a physiological process that occurs in melanosomes of melanocytes. Solar radiation modulates pigmentation through variety of signaling pathways, but the mechanism of visible light-induced hyperpigmentation remains uncharacterized. Passeron's group recently reported that visible light stimulates opsin3-regulated calcium-dependent microphthalmia-associated transcription factor activation that increases pigment gene expression and that it also causes the clustering of melanogenic enzymes. Together, these processes possibly contribute to long-lasting hyperpigmentation in the melanocompetent skins. (Copyright © 2017 The Author. Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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