| Autor: |
McMillen IC; Department of Physiology, Monash University, Clayton, Vic., Australia., Jenkin G, Haji-Baba AS, Browne CA, Thorburn GD |
| Jazyk: |
angličtina |
| Zdroj: |
Life sciences [Life Sci] 1989; Vol. 44 (8), pp. 563-9. |
| DOI: |
10.1016/0024-3205(89)90618-8 |
| Abstrakt: |
We have measured circulating concentrations of gamma 3 Melanocyte Stimulating Hormone (MSH) in fetal sheep between 111 and 145 days gestation. There was no significant effect of gestational age on the fetal plasma concentrations of gamma 3 MSH throughout this period. We have examined the role of gamma-MSH related peptides in the control of fetal adrenal steroidogenesis and found no significant change in fetal plasma cortisol or pregnenolone concentrations during a 60-72 h infusion of saline, gamma 2 MSH or gamma 3 MSH in sheep between 130 and 135 days gestation. Therefore although we have demonstrated the presence of gamma MSH related peptides in fetal sheep plasma during late gestation we have failed to demonstrate a role for gamma 3 or gamma 2 MSH in the changes in fetal steroid concentrations which occur prepartum. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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