Peroxisome proliferator-activated receptor-γ in induced sputum is correlated with MMP-9/TIMP-1 imbalance and formation of emphysema in COPD patients.
Autor: | Zhou XM; Department of Respiratory Medicine, Shengjing Hospital, China Medical University, Shenyang 110004, China.; Institute of Respiratory Disease, China Medical University, Shenyang 110001, China., Hou G; Institute of Respiratory Disease, China Medical University, Shenyang 110001, China.; Department of Respiratory Medicine, the First Hospital, China Medical University, Shenyang 110001, China., Gu DX; Department of Respiratory Medicine, People's Hospital of Liaoning Province, Shenyang 110016, China., Wang QY; Institute of Respiratory Disease, China Medical University, Shenyang 110001, China.; Department of Respiratory Medicine, the First Hospital, China Medical University, Shenyang 110001, China., Zhao L; Department of Respiratory Medicine, Shengjing Hospital, China Medical University, Shenyang 110004, China.; Institute of Respiratory Disease, China Medical University, Shenyang 110001, China. |
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Jazyk: | angličtina |
Zdroj: | Journal of thoracic disease [J Thorac Dis] 2017 Oct; Vol. 9 (10), pp. 3703-3710. |
DOI: | 10.21037/jtd.2017.09.10 |
Abstrakt: | Background: The development of chronic obstructive pulmonary disease (COPD) is modulated by the symmetry of matrix metalloproteinases (MMPs) and the counter-acting tissue inhibitors of metalloproteinases (TIMPs). We investigated the interaction between peroxisome proliferator-activated receptor gamma (PPARγ) expression and the imbalance of MMP-9/TIMP-1 in the induced sputum of stable COPD patients. Methods: Sixty-six stable COPD patients were enrolled and the induced sputum samples were gathered. The correlation between PPARγ and other index, including MMP-9, TIMP-1, pulmonary function and the index of emphysema-the percentage of low attenuation area (LAA%), was analyzed. Results: PPARγ and TIMP-1 concentrations were decreased and the concentration of MMP-9 and the ratio of MMP9/TIMP1 were enhanced in the induced sputum of COPD patients, compared to the healthy controls. Among COPD patients, those with worse lung function or patients with emphysema exhibited increased MMP-9 expression with decreased TIMP-1 and PPARγ expression. Besides, the concentration of PPARγ of the induced sputum was correlated with the forced expiratory volume in one second percentage (FEV1%) positively and the expression of TIMP-1; while it was negatively correlated with the residual volume (RV), RV/total lung capacity (TLC), LAA%, and MMP-9 expression. Conclusions: Our findings reveal the protective role of PPARγ in the maintenance of the dynamic balance of MMP-9/TIMP-1 in COPD, thus providing evidence on which to base the potential COPD treatment. Competing Interests: Conflicts of Interest: The authors have no conflicts of interest to declare. |
Databáze: | MEDLINE |
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