Low bone mineral density among HIV-infected patients in Brazil.

Autor:	Chaba DCDS; Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Ambulatório de Imunodeficiência Secundária, São Paulo, São Paulo, Brazil.; Universidade de São Paulo, Faculdade de Medicina, Laboratório de Investigação Médica em Neurologia (LIM 56), São Paulo, São Paulo, Brazil.; University of California, Global Health Sciences, San Francisco, California, USA., Soares LR; Universidade Federal do Rio de Janeiro, Cursos de Nutrição, Rio de Janeiro, Rio de Janeiro, Brazil., Pereira RMR; Universidade de São Paulo, Faculdade de Medicina, Disciplina de Reumatologia, Laboratório de Metabolismo Ósseo São Paulo, São Paulo, Brazil., Rutherford GW; University of California, Global Health Sciences, San Francisco, California, USA., Assone T; Universidade de São Paulo, Faculdade de Medicina, Laboratório de Investigação Médica em Neurologia (LIM 56), São Paulo, São Paulo, Brazil., Takayama L; Universidade de São Paulo, Faculdade de Medicina, Disciplina de Reumatologia, Laboratório de Metabolismo Ósseo São Paulo, São Paulo, Brazil., Fonseca LAM; Universidade de São Paulo, Faculdade de Medicina, Departamento de Medicina Preventiva, (LIM 38), São Paulo, São Paulo, Brazil., Duarte AJS; Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Ambulatório de Imunodeficiência Secundária, São Paulo, São Paulo, Brazil., Casseb J; Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Ambulatório de Imunodeficiência Secundária, São Paulo, São Paulo, Brazil.; Universidade de São Paulo, Faculdade de Medicina, Laboratório de Investigação Médica em Neurologia (LIM 56), São Paulo, São Paulo, Brazil.; Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo, São Paulo, São Paulo, Brazil.
Jazyk:	angličtina
Zdroj:	Revista do Instituto de Medicina Tropical de Sao Paulo [Rev Inst Med Trop Sao Paulo] 2017 Dec 21; Vol. 59, pp. e89. Date of Electronic Publication: 2017 Dec 21.
DOI:	10.1590/S1678-9946201759089
Abstrakt:	Decrease in bone mineral density (BMD) has been a complication among people living with HIV/AIDS. To investigate the prevalence of osteopenia/osteoporosis among HIV-infected people living in São Paulo city, we studied 108 HIV-infected patients (79 men and 29 women). We extracted data from patients' medical records and BMD was measured by dual-energy X-ray absorptiometry (DXA). Median age of participants was 42 years (interquartile range [IQR] 36-48 years), and the median time since HIV diagnosis was 4.01 years (IQR 2-11 years). Patients had acquired HIV primarily by the sexual route (men who have sex with men 44%, heterosexual 49%). Median age, duration of HIV infection, duration of ART and CD4 nadir were similar for men and women. Plasma viral load was undetectable for 53 patients (49%). Median CD4 T cell count was 399 cells/µL (IQR 247 - 568). Twenty five patients (23%) had LBMD, and there was no statistically significant difference between men and women (<-1). The associated risk factors for LBMD were older age (≥ 50 years old) and smoking with a RR of 3.87 and 2.80, respectively. Thus, despite the lack of statistically significant relationship between the use of ART and LBMD or between duration of ART and LBMD, these factors should be addressed in larger studies.
Databáze:	MEDLINE
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