Combination therapeutic options in the treatment of the luteal phase deficiency.

Autor: Orazov MR; a Peoples Friendship University of Russia (RUDN University) , Moscow , Russian Federation., Radzinskiy VE; a Peoples Friendship University of Russia (RUDN University) , Moscow , Russian Federation., Nosenko EN; b Odessa National Medical University, Ministry of Health of the Ukraine , Odessa , Ukraine., Khamoshina MB; a Peoples Friendship University of Russia (RUDN University) , Moscow , Russian Federation., Lebedeva MG; a Peoples Friendship University of Russia (RUDN University) , Moscow , Russian Federation., Tokaeva ES; a Peoples Friendship University of Russia (RUDN University) , Moscow , Russian Federation., Barsegyan LK; a Peoples Friendship University of Russia (RUDN University) , Moscow , Russian Federation., Novginov DS; a Peoples Friendship University of Russia (RUDN University) , Moscow , Russian Federation., Zakirova YR; a Peoples Friendship University of Russia (RUDN University) , Moscow , Russian Federation., Minayeva AV; a Peoples Friendship University of Russia (RUDN University) , Moscow , Russian Federation.
Jazyk: angličtina
Zdroj: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2017; Vol. 33 (sup1), pp. 1-4.
DOI: 10.1080/09513590.2017.1399695
Abstrakt: Luteal phase deficiency (LPD) is described as a condition of insufficient progesterone exposure to maintain a regular secretory endometrium and allow for normal embryo implantation and growth. There is evidence that both follicular and luteal phase abnormalities can result in LPD cycles. The aim of this randomized prospective noncomparative study is to evaluate the effectiveness of combination therapy in patients with LPD. This prospective study included 35 women of the reproductive age. They were diagnosed with the LPD with sonographically and laboratory-verified methods. The age of patients was 36 ± 0.46 years. The results of the study sonographically demonstrated an increase in the diameter of the corpus luteum from 1.36 ± 0.32 (initially) to 2.16 ± 0.21 mm after combination therapy. In addition, there was a statistically significant increase in the level of estrogens and progesterone in the corresponding phases of the menstrual cycle. Thus, the combination therapy for patients with LPD contributes to the recovery of cyclic events in the hypothalamic-pituitary-gonadal system, which determines the restoration of the endocrine function of the ovaries and promotes adequate secretory rearrangement of the endometrium in women of reproductive age.
Databáze: MEDLINE
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