Nonalcoholic Fatty Liver Disease in Hispanic Youth With Dysglycemia: Risk for Subclinical Atherosclerosis?
| Autor: | Bacha F; United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77030.; Division of Pediatric Diabetes and Endocrinology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77030., Tomsa A; United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77030.; Division of Pediatric Diabetes and Endocrinology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77030., Bartz SK; United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77030.; Division of Pediatric Diabetes and Endocrinology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77030., Barlow SE; Division of Gastroenterology, Hepatology, and Nutrition, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77030., Chu ZD; Division of Radiology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77030., Krishnamurthy R; Division of Radiology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77030., Krishnamurthy R; Division of Radiology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77030., Smith EO; United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas 77030. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of the Endocrine Society [J Endocr Soc] 2017 Jun 27; Vol. 1 (8), pp. 1029-1040. Date of Electronic Publication: 2017 Jun 27 (Print Publication: 2017). |
| DOI: | 10.1210/js.2017-00257 |
| Abstrakt: | Context: Obese Hispanic adolescents (OHAs) with dysglycemia have increased cardiovascular disease risk burden. Objective: To investigate if nonalcoholic fatty liver disease (NAFLD) confers added risk for endothelial dysfunction in these youth. Design: Cross-sectional study. Setting: Academic institution. Participants: Thirty-six OHAs (15.3 ± 0.4 years), 20 with prediabetes and 16 with type 2 diabetes, with and without NAFLD. Intervention: Evaluation of reactive hyperemia index (RHI) and augmentation index (AIx) by peripheral arterial tonometry; muscle, hepatic, and adipose tissue insulin sensitivity (IS; hyperinsulinemic-euglycemic clamp 80 mu/m 2 /min, with [6,6 2 H Outcome Measures: RHI and AIx. Hypothesis: OHAs with dysglycemia and NAFLD have worse RHI and AIx vs those without NAFLD. Results: The NAFLD (n = 23) and non-NAFLD (n = 13) groups were of similar age, sex, glycemic status, body mass index, % body fat and abdominal fat. The NAFLD group had higher hepatic fat ( P < 0.001) lower skeletal muscle IS ( P = 0.01), hepatic IS ( P = 0.01), and adipose tissue IS ( P = 0.04). The NAFLD vs non-NAFLD group had lower RHI (1.4 ± 0.05 vs 1.7 ± 0.09, P = 0.002), greater AIx (-6.0 ± 1.6 vs -12.0 ± 2.1, P = 0.03). Hepatic fat was inversely related to RHI ( r = -0.49, P = 0.002) and positively related to AIx ( r = 0.45, P = 0.006). Hepatic IS ( r = -0.42, P = 0.01) and adipose IS ( r = -.54, P = 0.001) correlated with arterial stiffness (AIx). Conclusion: In OHAs with dysglycemia, NAFLD is associated with worse endothelial function. RHI and AIx were related to hepatic fat content. Vascular stiffness was related to hepatic and adipose tissue insulin resistance. |
| Databáze: | MEDLINE |
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