A new synthetic granular calcium phosphate compound induces new bone in a sinus lift rabbit model.

Autor: Trbakovic A; Department of Surgical Sciences, Plastic & Oral and Maxillofacial Surgery, Uppsala University, 751 85 Uppsala, Sweden. Electronic address: amela.trbakovic@surgsci.uu.se., Hedenqvist P; Swedish University of Agricultural Sciences, Department of Clinical Sciences, PO Box 7054, 750 07 Uppsala, Sweden. Electronic address: patricia.hedenqvist@slu.se., Mellgren T; Polymer Chemistry, Department of Chemistry, Ångströms Laboratory, Uppsala University, Box 538, 75121 Uppsala, Sweden. Electronic address: torbjorn.mellgren@angstrom.uu.se., Ley C; Swedish University of Agricultural Sciences, Department of Biomedical Sciences and Veterinary Public Health, Division of Pathology, PO Box 7028, 750 07 Uppsala, Sweden. Electronic address: cecilia.ley@slu.se., Hilborn J; Polymer Chemistry, Department of Chemistry, Ångströms Laboratory, Uppsala University, Box 538, 75121 Uppsala, Sweden. Electronic address: jons.hilborn@kemi.uu.se., Ossipov D; Polymer Chemistry, Department of Chemistry, Ångströms Laboratory, Uppsala University, Box 538, 75121 Uppsala, Sweden., Ekman S; Swedish University of Agricultural Sciences, Department of Biomedical Sciences and Veterinary Public Health, Division of Pathology, PO Box 7028, 750 07 Uppsala, Sweden. Electronic address: stina.ekman@slu.se., Johansson CB; University of Gothenburg, The Sahlgrenska Academy, Institute of Odontology, Department of Prosthodontics, Dental Materials Science, P.O. Box 450, 405 30 Gothenburg, Sweden. Electronic address: carina.johansson@biomaterials.gu.se., Jensen-Waern M; Swedish University of Agricultural Sciences, Department of Clinical Sciences, PO Box 7054, 750 07 Uppsala, Sweden. Electronic address: marianne.jensen-waern@slu.se., Thor A; Department of Surgical Sciences, Plastic & Oral and Maxillofacial Surgery, Uppsala University, 751 85 Uppsala, Sweden. Electronic address: andreas.thor@akademiska.se.
Jazyk: angličtina
Zdroj: Journal of dentistry [J Dent] 2018 Mar; Vol. 70, pp. 31-39. Date of Electronic Publication: 2017 Dec 16.
DOI: 10.1016/j.jdent.2017.12.009
Abstrakt: Objectives: The aim of this study was to investigate if a synthetic granular calcium phosphate compound (CPC) and a composite bisphosphonate-linked hyaluronic acid-calcium phosphate hydrogel (HABP·CaP) induced similar or more amount of bone as bovine mineral in a modified sinus lift rabbit model.
Material and Methods: Eighteen adult male New Zeeland White rabbits, received randomly one of the two test materials on a random side of the face, and bovine mineral as control on the contralateral side. In a sinus lift, the sinus mucosa was elevated and a titanium mini-implant was placed in the alveolar bone. Augmentation material (CPC, HABP·CaP or bovine bone) was applied in the space around the implant. The rabbits were euthanized three months after surgery and qualitative and histomorphometric evaluation were conducted. Histomorphometric evaluation included three different regions of interest (ROIs) and the bone to implant contact on each installed implant.
Results: Qualitative assessment (p = <.05), histomorphometric evaluations (p = < .01), and implant incorporation (p = <.05) showed that CPC and bovine mineral induced similar amount of bone and more than the HABP·CaP hydrogel.
Conclusion: CPC induced similar amount of bone as bovine mineral and both materials induced more bone than HABP·CaP hydrogel.
Clinical Significance: The CPC is suggested as a synthetic alternative for augmentations in the maxillofacial area.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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