Adipokines in hereditary breast cancer patients and healthy relatives.

Autor:	Sambiasi D; Experimental Medical Oncology, IRCCS Istituto Tumori 'Giovanni Paolo II', 70124 Bari, Italy., De Summa S; Molecular Genetic Laboratory, IRCCS Istituto Tumori 'Giovanni Paolo II', 70124 Bari, Italy., Digennaro M; Experimental Medical Oncology, IRCCS Istituto Tumori 'Giovanni Paolo II', 70124 Bari, Italy., Pilato B; Molecular Genetic Laboratory, IRCCS Istituto Tumori 'Giovanni Paolo II', 70124 Bari, Italy., Paradiso A; Experimental Medical Oncology, IRCCS Istituto Tumori 'Giovanni Paolo II', 70124 Bari, Italy., Tommasi S; Molecular Genetic Laboratory, IRCCS Istituto Tumori 'Giovanni Paolo II', 70124 Bari, Italy.
Jazyk:	angličtina
Zdroj:	Oncotarget [Oncotarget] 2017 Sep 18; Vol. 8 (60), pp. 101255-101261. Date of Electronic Publication: 2017 Sep 18 (Print Publication: 2017).
DOI:	10.18632/oncotarget.21018
Abstrakt:	Background: The role of adipocytokines and ghrelin in hereditary breast cancer syndrome (HBCS) has never been tested. Results: No significant differences in leptin, adiponectin and ghrelin plasma levels between cancer patients and healthy subjects was observed. Conversely, an higher level of adiponectin was shown in healthy subjects with BRCA 1/2 gene mutation vs those without ( p < 0.03). Logistic regression analysis demonstrated that Adiponectin plasma level (OR 0.26; 95% CI:0.007-0.81; p < 0.02) and age (OR 5.51; 95% CI:1.78-19.71; p < 0.004) were the only factors independently associated with BMI; furthermore, Leptin plasma level (OR 0.23; 95% CI:0.06-0.76; p < 0.01) and age (OR 0.05; 95% CI:0.05-0.61; p < 0.007) resulted the only factors significantly associated with breast cancer. Materials and Methods: We analyzed blood plasma expression of leptin, adiponectin and ghrelin using Bio-Plex platform in 25 breast cancer patients with HBCS and in 38 healthy relatives. BRCA 1/2 gene status (presence of pathogenic mutations by direct molecular sequencing), clinical-pathological characteristics and Body Mass Index (BMI) of each subject were recorded. Conclusions: Adiponectin confirms to be associated with BMI also in subjects with HBCS. Leptin plasma level seems a direct and independent biomarker of a breast cancer risk. A validation of Leptin as a circulating biomarker of breast cancer development in larger series of HBCS subjects is needed. Competing Interests: CONFLICTS OF INTEREST No conflicts of interest was declared by all the Authors.
Databáze:	MEDLINE
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