Intrathecal synthesis of oligoclonal IgG in patients with Viliuisk encephalomyelitis: The relationship between oligoclonal bands and clinical features.

Autor: Sivtseva TM; Institute of Health, North-Eastern Federal University, Yakutsk, Russia. Electronic address: tm.sivtseva@s-vfu.ru., Vladimirtsev VA; Institute of Health, North-Eastern Federal University, Yakutsk, Russia., Nikitina RS; Institute of Health, North-Eastern Federal University, Yakutsk, Russia., Davidova TK; Institute of Health, North-Eastern Federal University, Yakutsk, Russia., Popov DA; Department of Radiology, Republican Hospital #2 - Center of Emergency Medicine, Yakutsk, Russia., Osakovsky VL; Institute of Health, North-Eastern Federal University, Yakutsk, Russia.
Jazyk: angličtina
Zdroj: Journal of the neurological sciences [J Neurol Sci] 2018 Jan 15; Vol. 384, pp. 84-88. Date of Electronic Publication: 2017 Nov 22.
DOI: 10.1016/j.jns.2017.11.030
Abstrakt: Viliuisk encephalomyelitis (VE) is a neurodegenerative disease that afflicts aboriginal people of Yakutia in Siberia with unknown etiology. Oligoclonal IgG bands (OCBs) were discovered in the VE patients (Green et al., 2003). In this study we analysed the association of OCBs with clinical symptoms in 58 VE patients. Positive oligoclonal IgG are associated with a shorter duration of disease (p=0.002), older age of onset (p=0.023) and high frequency of main neurological VE symptoms such as dementia, frontal dysbasia, bulbar disorders, muscle atrophy and centrally caused pelvic disorders. Our results show that the OCBs in VE patients are associated with more severe central nervous system (CNS) damage and may cause secondary complications in the course of the disease.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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