Rapid emergence of colistin resistance and its impact on fatality among healthcare-associated infections.

Autor: Aydın M; Infectious Diseases and Clinical Microbiology Department, School of Medicine, Başkent University, Istanbul, Turkey. Electronic address: mehtapaydin10@gmail.com., Ergönül Ö; Infectious Diseases and Clinical Microbiology Department, School of Medicine, Koç University, Istanbul, Turkey., Azap A; Infectious Diseases and Clinical Microbiology Department, School of Medicine, Ankara University, Ankara, Turkey., Bilgin H; Infectious Diseases and Clinical Microbiology Department, School of Medicine, Marmara University, Istanbul, Turkey., Aydın G; Infectious Diseases and Clinical Microbiology Department, School of Medicine, Ankara University, Ankara, Turkey; Infectious Diseases and Clinical Microbiology Department, Afyonkarahisar Training and Research Hospital, Afyonkarahisar, Turkey., Çavuş SA; Infectious Diseases and Clinical Microbiology Department, School of Medicine, Dokuz Eylül University, İzmir, Turkey., Demiroğlu YZ; Infectious Diseases and Clinical Microbiology Department, School of Medicine, Başkent University, Adana, Turkey., Alışkan HE; Clinical Microbiology Department, School of Medicine, Başkent University, Adana, Turkey., Memikoğlu O; Infectious Diseases and Clinical Microbiology Department, School of Medicine, Ankara University, Ankara, Turkey., Menekşe Ş; Infectious Diseases and Clinical Microbiology Department, SBÜ Kartal Koşuyolu Yüksek İhtisas Hospital, Training and Research Hospital, Istanbul, Turkey., Kaya Ş; Infectious Diseases and Clinical Microbiology Department, Diyarbakır Training and Research Hospital, Diyarbakır, Turkey., Demir NA; Infectious Diseases and Clinical Microbiology Department, School of Medicine, Selçuk University, Konya, Turkey., Karaoğlan I; Infectious Diseases and Clinical Microbiology Department, School of Medicine, Gaziantep University, Gaziantep, Turkey., Başaran S; Infectious Diseases and Clinical Microbiology Department, School of Medicine, İstanbul University, Istanbul, Turkey., Hatipoğlu Ç; Infectious Diseases and Clinical Microbiology Department, Ankara Training and Research Hospital, Ankara, Turkey., Erdinç Ş; Infectious Diseases and Clinical Microbiology Department, Ankara Training and Research Hospital, Ankara, Turkey., Yılmaz E; Infectious Diseases and Clinical Microbiology Department, School of Medicine, Uludağ University, Bursa, Turkey., Tümtürk A; Infectious Diseases and Clinical Microbiology Department, Ankara Yüksek İhtisas Training and Research Hospital, Ankara, Turkey., Tezer Y; Infectious Diseases and Clinical Microbiology Department, Ankara Yüksek İhtisas Training and Research Hospital, Ankara, Turkey., Demirkaya H; Infectious Diseases and Clinical Microbiology Department, School of Medicine, Başkent University, Ankara, Turkey., Çakar ŞE; Infectious Diseases and Clinical Microbiology Department, Ümraniye Training and Research Hospital, Istanbul, Turkey., Keske Ş; Infectious Diseases and Clinical Microbiology Department, School of Medicine, Koç University, Istanbul, Turkey., Tekin S; Infectious Diseases and Clinical Microbiology Department, School of Medicine, Koç University, Istanbul, Turkey., Yardımcı C; Infectious Diseases and Clinical Microbiology Department, Şanlıurfa Training and Research Hospital, Şanlıurfa, Turkey., Karakoç Ç; Infectious Diseases and Clinical Microbiology Department, School of Medicine, İstinye University, Istanbul, Turkey., Ergen P; Infectious Diseases and Clinical Microbiology Department, School of Medicine, Medeniyet University, Istanbul, Turkey., Azap Ö; Infectious Diseases and Clinical Microbiology Department, School of Medicine, Başkent University, Ankara, Turkey., Mülazımoğlu L; Infectious Diseases and Clinical Microbiology Department, School of Medicine, Marmara University, Istanbul, Turkey., Ural O; Infectious Diseases and Clinical Microbiology Department, School of Medicine, Selçuk University, Konya, Turkey., Can F; Clinical Microbiology Department, School of Medicine, Koç University, Istanbul, Turkey., Akalın H; Infectious Diseases and Clinical Microbiology Department, School of Medicine, Uludağ University, Bursa, Turkey.
Jazyk: angličtina
Zdroj: The Journal of hospital infection [J Hosp Infect] 2018 Mar; Vol. 98 (3), pp. 260-263. Date of Electronic Publication: 2017 Dec 15.
DOI: 10.1016/j.jhin.2017.11.014
Abstrakt: This article describes the emergence of resistance and predictors of fatality for 1556 cases of healthcare-associated Gram-negative bloodstream infection in 2014 and 2015. The colistin resistance rate in Klebsiella pneumoniae was 16.1%, compared with 6% in 2013. In total, 660 (42.4%) cases were fatal. The highest fatality rate was among patients with Acinetobacter baumannii bacteraemia (58%), followed by Pseudomonas aeruginosa (45%), Klebsiella pneumoniae (41%), Enterobacter cloacae (32%) and Escherichia coli (28%). On multi-variate analysis, the minimum inhibitory concentrations for carbapenems [odds ratio (OR) 1.02, 95% confidence interval (CI) 1.01-1.04; P = 0.002] and colistin (OR 1.1, 95% CI 1.03-1.17; P = 0.001) were found to be significantly associated with fatality.
(Copyright © 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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