Racemization of aspartyl residues in proteins from normal and cataractous human lenses: an aging process without involvement in cataract formation.

Autor: van den Oetelaar PJ; Department of Biochemistry, University of Nijmegen, The Netherlands., Hoenders HJ
Jazyk: angličtina
Zdroj: Experimental eye research [Exp Eye Res] 1989 Feb; Vol. 48 (2), pp. 209-14.
DOI: 10.1016/s0014-4835(89)80070-3
Abstrakt: A highly sensitive method was used to determine D- and L-aspartyl residues in protein fractions from normal and cataractous human lenses. A linear relationship with age was found in all fractions from normal lenses. However, no correlation with cataract could be established. It is concluded that racemization of aspartyl residues is a continuous process in eye-lens proteins but plays no role in cataract formation.
Databáze: MEDLINE