The BRICS (Bronchiectasis Radiologically Indexed CT Score): A Multicenter Study Score for Use in Idiopathic and Postinfective Bronchiectasis.

Autor: Bedi P; MRC Center for Inflammation Research, Queen's Medical Research Institute, Edinburgh, UK. Electronic address: drpallavibedi@gmail.com., Chalmers JD; School of Medicine, University of Dundee, Dundee, UK., Goeminne PC; Department of Respiratory Disease, AZ Nikolaas, Sint-Niklaas, Belgium., Mai C; University Hospitals of Leuven, Department of Radiology, Leuven, Belgium., Saravanamuthu P; Royal Infirmary of Edinburgh, Edinburgh, UK., Velu PP; Royal Infirmary of Edinburgh, Edinburgh, UK., Cartlidge MK; MRC Center for Inflammation Research, Queen's Medical Research Institute, Edinburgh, UK., Loebinger MR; Royal Brompton, London, UK., Jacob J; Royal Brompton, London, UK., Kamal F; Royal Brompton, London, UK., Schembri N; School of Medicine, University of Dundee, Dundee, UK., Aliberti S; Department of Pathophysiology and Transplantation, University of Milan Internal Medicine Department, Respiratory Unit and Cystic Fibrosis Adult Center Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Hill U; Cambridge Center for Lung Infection, Papworth Hospital, Cambridge, UK., Harrison M; Cambridge Center for Lung Infection, Papworth Hospital, Cambridge, UK., Johnson C; Cambridge Center for Lung Infection, Papworth Hospital, Cambridge, UK., Screaton N; Cambridge Center for Lung Infection, Papworth Hospital, Cambridge, UK., Haworth C; Cambridge Center for Lung Infection, Papworth Hospital, Cambridge, UK., Polverino E; Institut Clínic del Tòrax, Hospital Clínic de Barcelona, Barcelona, Spain., Rosales E; Institut Clínic del Tòrax, Hospital Clínic de Barcelona, Barcelona, Spain., Torres A; Institut Clínic del Tòrax, Hospital Clínic de Barcelona, Barcelona, Spain., Benegas MN; Institut Clínic del Tòrax, Hospital Clínic de Barcelona, Barcelona, Spain., Rossi AG; MRC Center for Inflammation Research, Queen's Medical Research Institute, Edinburgh, UK., Patel D; Royal Infirmary of Edinburgh, Edinburgh, UK., Hill AT; MRC Center for Inflammation Research, Queen's Medical Research Institute, Edinburgh, UK; Royal Infirmary of Edinburgh, Edinburgh, UK.
Jazyk: angličtina
Zdroj: Chest [Chest] 2018 May; Vol. 153 (5), pp. 1177-1186. Date of Electronic Publication: 2017 Dec 13.
DOI: 10.1016/j.chest.2017.11.033
Abstrakt: Objectives: The goal of this study was to develop a simplified radiological score that could assess clinical disease severity in bronchiectasis.
Methods: The Bronchiectasis Radiologically Indexed CT Score (BRICS) was devised based on a multivariable analysis of the Bhalla score and its ability in predicting clinical parameters of severity. The score was then externally validated in six centers in 302 patients.
Results: A total of 184 high-resolution CT scans were scored for the validation cohort. In a multiple logistic regression model, disease severity markers significantly associated with the Bhalla score were percent predicted FEV 1 , sputum purulence, and exacerbations requiring hospital admission. Components of the Bhalla score that were significantly associated with the disease severity markers were bronchial dilatation and number of bronchopulmonary segments with emphysema. The BRICS was developed with these two parameters. The receiver operating-characteristic curve values for BRICS in the derivation cohort were 0.79 for percent predicted FEV 1 , 0.71 for sputum purulence, and 0.75 for hospital admissions per year; these values were 0.81, 0.70, and 0.70, respectively, in the validation cohort. Sputum free neutrophil elastase activity was significantly elevated in the group with emphysema on CT imaging.
Conclusions: A simplified CT scoring system can be used as an adjunct to clinical parameters to predict disease severity in patients with idiopathic and postinfective bronchiectasis.
(Copyright © 2017 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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