Compact dual-mode diffuse optical system for blood perfusion monitoring in a porcine model of microvascular tissue flaps.

Autor:	Lee SY; University of Michigan, Department of Biomedical Engineering, Ann Arbor, Michigan, United States., Pakela JM; University of Michigan, Applied Physics Program, Ann Arbor, Michigan, United States., Helton MC; University of Michigan, Department of Biomedical Engineering, Ann Arbor, Michigan, United States.; University of Michigan, Applied Physics Program, Ann Arbor, Michigan, United States., Vishwanath K; Miami University, Department of Physics, Oxford, Ohio, United States., Chung YG; University of Michigan, Department of Biomedical Engineering, Ann Arbor, Michigan, United States., Kolodziejski NJ; Radiation Monitoring Devices Inc., Watertown, Massachusetts, United States., Stapels CJ; Radiation Monitoring Devices Inc., Watertown, Massachusetts, United States., McAdams DR; Radiation Monitoring Devices Inc., Watertown, Massachusetts, United States., Fernandez DE; Radiation Monitoring Devices Inc., Watertown, Massachusetts, United States., Christian JF; Radiation Monitoring Devices Inc., Watertown, Massachusetts, United States., O'Reilly J; Radiation Monitoring Devices Inc., Watertown, Massachusetts, United States.; Northeastern University, Boston, Massachusetts, United States., Farkas D; Radiation Monitoring Devices Inc., Watertown, Massachusetts, United States.; Northeastern University, Boston, Massachusetts, United States., Ward BB; University of Michigan, Department of Oral and Maxillofacial Surgery, Ann Arbor, Michigan, United States., Feinberg SE; University of Michigan, Department of Oral and Maxillofacial Surgery, Ann Arbor, Michigan, United States., Mycek MA; University of Michigan, Department of Biomedical Engineering, Ann Arbor, Michigan, United States.; University of Michigan, Applied Physics Program, Ann Arbor, Michigan, United States.
Jazyk:	angličtina
Zdroj:	Journal of biomedical optics [J Biomed Opt] 2017 Dec; Vol. 22 (12), pp. 1-14.
DOI:	10.1117/1.JBO.22.12.121609
Abstrakt:	In reconstructive surgery, the ability to detect blood flow interruptions to grafted tissue represents a critical step in preventing postsurgical complications. We have developed and pilot tested a compact, fiber-based device that combines two complimentary modalities-diffuse correlation spectroscopy (DCS) and diffuse reflectance spectroscopy-to quantitatively monitor blood perfusion. We present a proof-of-concept study on an in vivo porcine model (n=8). With a controllable arterial blood flow supply, occlusion studies (n=4) were performed on surgically isolated free flaps while the device simultaneously monitored blood flow through the supplying artery as well as flap perfusion from three orientations: the distal side of the flap and two transdermal channels. Further studies featuring long-term monitoring, arterial failure simulations, and venous failure simulations were performed on flaps that had undergone an anastomosis procedure (n=4). Additionally, benchtop verification of the DCS system was performed on liquid flow phantoms. Data revealed relationships between diffuse optical measures and state of occlusion as well as the ability to detect arterial and venous compromise. The compact construction of the device, along with its noninvasive and quantitative nature, would make this technology suitable for clinical translation. ((2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE).)
Databáze:	MEDLINE
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