| Autor: |
Walcher DL; Post-Graduate Program in Parasitology, Department of Microbiology and Parasitology, Universidade Federal de Pelotas (UFPel), Pelotas, Rio Grande do Sul, Brazil. ldeborah@hotmail.com.; Laboratory Parasitology - Universidade Federal do Rio Grande, Rua General Osório S/N, Rio Grande, CEP 96203900, Rio Grande do Sul, Brazil. ldeborah@hotmail.com., Cruz LAX; Post-Graduate Program in Health Sciences - Parasitology Laboratory, Universidade Federal do Rio Grande (FURG), Academic Area of the University Hospital - FURG, Rio Grande, Rio Grande do Sul, Brazil., de Lima Telmo P; Parasitology Laboratory, Universidade Federal do Rio Grande (FURG), Academic Area of the University Hospital - FURG, Rio Grande, Rio Grande do Sul, Brazil., Martins LHR; Parasitology Laboratory, Universidade Federal do Rio Grande (FURG), Academic Area of the University Hospital - FURG, Rio Grande, Rio Grande do Sul, Brazil., da Costa de Avila LF; Post-Graduate Program in Health Sciences - Parasitology Laboratory, Universidade Federal do Rio Grande (FURG), Academic Area of the University Hospital - FURG, Rio Grande, Rio Grande do Sul, Brazil., Berne MEA; Post-Graduate Program in Parasitology, Department of Microbiology and Parasitology, Universidade Federal de Pelotas (UFPel), Pelotas, Rio Grande do Sul, Brazil., Scaini CJ; Post-Graduate Program in Health Sciences - Parasitology Laboratory, Universidade Federal do Rio Grande (FURG), Academic Area of the University Hospital - FURG, Rio Grande, Rio Grande do Sul, Brazil. |
| Abstrakt: |
Human toxocariasis is a neglected global parasitic zoonosis. The efficacy of drug treatment for this disease has been hindered by the biological complexity of the main etiological agent, the nematode Toxocara canis. Experimental studies have shown the potential of probiotics to promote a reduction in the parasite load of T. canis larvae. This study aimed to evaluate the effect of probiotic Lactobacillus rhamnosus ATCC 7469 on the parasite load of BALB/c mice with acute toxocariasis and evaluate the direct effect of this probiotic on T. canis larvae in vitro. In vivo administration of probiotics reduced the parasite load of T. canis larvae by 53.3% (p = 0.0018) during the early stage of infection in mice. However, when analyzed in vitro, it was observed that the probiotic did not present a deleterious effect on the larvae, as approximately 90% of these remained viable. These results demonstrate the potential of the probiotic L. rhamnosus in the reduction of T. canis larvae in BALB/c mice and suggest it could be used as an alternative means for the controlling of visceral toxocariasis. However, further studies are required to elucidate the mechanisms of action promoted by this probiotic. |
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