Deciphering psoriasis. A bioinformatic approach.

Autor: Melero JL; Department of Biochemistry and Biotechnology, Rovira i Virgili University, Tarragona, Spain., Andrades S; Department of Biochemistry and Biotechnology, Rovira i Virgili University, Tarragona, Spain., Arola L; Department of Biochemistry and Biotechnology, Rovira i Virgili University, Tarragona, Spain., Romeu A; Department of Biochemistry and Biotechnology, Rovira i Virgili University, Tarragona, Spain. Electronic address: antoni.romeu@urv.cat.
Jazyk: angličtina
Zdroj: Journal of dermatological science [J Dermatol Sci] 2018 Feb; Vol. 89 (2), pp. 120-126. Date of Electronic Publication: 2017 Nov 22.
DOI: 10.1016/j.jdermsci.2017.11.010
Abstrakt: Background: Psoriasis is an immune-mediated, inflammatory and hyperproliferative disease of the skin and joints. The cause of psoriasis is still unknown. The fundamental feature of the disease is the hyperproliferation of keratinocytes and the recruitment of cells from the immune system in the region of the affected skin, which leads to deregulation of many well-known gene expressions.
Objective: Based on data mining and bioinformatic scripting, here we show a new dimension of the effect of psoriasis at the genomic level.
Methods: Using our own pipeline of scripts in Perl and MySql and based on the freely available NCBI Gene Expression Omnibus (GEO) database: DataSet Record GDS4602 (Series GSE13355), we explore the extent of the effect of psoriasis on gene expression in the affected tissue.
Results: We give greater insight into the effects of psoriasis on the up-regulation of some genes in the cell cycle (CCNB1, CCNA2, CCNE2, CDK1) or the dynamin system (GBPs, MXs, MFN1), as well as the down-regulation of typical antioxidant genes (catalase, CAT; superoxide dismutases, SOD1-3; and glutathione reductase, GSR). We also provide a complete list of the human genes and how they respond in a state of psoriasis.
Conclusion: Our results show that psoriasis affects all chromosomes and many biological functions. If we further consider the stable and mitotically inheritable character of the psoriasis phenotype, and the influence of environmental factors, then it seems that psoriasis has an epigenetic origin. This fit well with the strong hereditary character of the disease as well as its complex genetic background.
(Copyright © 2017 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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