Pediatric Multiple Sclerosis in Tunisia: A Retrospective Study over 11 Years.

Autor: Ben Achour N; Research Unit UR12 SP24 and Department of Child and Adolescent Neurology, National Institute Mongi Ben Hmida of Neurology, Tunis, Tunisia.; Faculty of Medicine of Tunis, Tunis El Manar University, 1007 Tunis, Tunisia., Rebai I; Research Unit UR12 SP24 and Department of Child and Adolescent Neurology, National Institute Mongi Ben Hmida of Neurology, Tunis, Tunisia., Raddadi S; Research Unit UR12 SP24 and Department of Child and Adolescent Neurology, National Institute Mongi Ben Hmida of Neurology, Tunis, Tunisia., Benrhouma H; Research Unit UR12 SP24 and Department of Child and Adolescent Neurology, National Institute Mongi Ben Hmida of Neurology, Tunis, Tunisia.; Faculty of Medicine of Tunis, Tunis El Manar University, 1007 Tunis, Tunisia., Klaa H; Research Unit UR12 SP24 and Department of Child and Adolescent Neurology, National Institute Mongi Ben Hmida of Neurology, Tunis, Tunisia.; Faculty of Medicine of Tunis, Tunis El Manar University, 1007 Tunis, Tunisia., Rouissi A; Research Unit UR12 SP24 and Department of Child and Adolescent Neurology, National Institute Mongi Ben Hmida of Neurology, Tunis, Tunisia., Kraoua I; Research Unit UR12 SP24 and Department of Child and Adolescent Neurology, National Institute Mongi Ben Hmida of Neurology, Tunis, Tunisia.; Faculty of Medicine of Tunis, Tunis El Manar University, 1007 Tunis, Tunisia., Ben Youssef Turki I; Research Unit UR12 SP24 and Department of Child and Adolescent Neurology, National Institute Mongi Ben Hmida of Neurology, Tunis, Tunisia.; Faculty of Medicine of Tunis, Tunis El Manar University, 1007 Tunis, Tunisia.
Jazyk: angličtina
Zdroj: BioMed research international [Biomed Res Int] 2017; Vol. 2017, pp. 4354826. Date of Electronic Publication: 2017 Nov 07.
DOI: 10.1155/2017/4354826
Abstrakt: Introduction: Pediatric multiple sclerosis (pMS) is a rare demyelinating disorder with an onset before the age of 18 years. In this study, we aimed to investigate the characteristics of pMS in Tunisian children.
Patients and Methods: We conducted a retrospective study over 11 years (2005-2016) including all patients diagnosed with pMS according to the International Pediatric Multiple Sclerosis Study Group (IPMSSG) criteria of 2012 and followed up in a tertiary care research center. Epidemiological, clinical, neuroimaging, laboratory, and therapeutic data were collected and analyzed.
Results: There were 21 patients. The male-female ratio was 1 : 3. Mean age at onset was 11 years (range: 3-17 years). Three patients had type 1 diabetes. Polyfocal presentation was preponderant (81%) with motor dysfunction in 57% of patients. Paroxysmal dystonia was noticed in 24%. All patients were diagnosed with relapsing-remitting form. Interferon beta was prescribed in 80% with a reduction of annual relapse rate.
Conclusion: The annual incidence of pMS in Tunisian children aged below 18 years could be estimated as 0.05 per 100,000. Singular features in our cohort were the frequent association with type 1 diabetes and the increased occurrence of dystonia. Greater awareness of pMS may be helpful to improve management strategies of children and their families.
Databáze: MEDLINE
Externí odkaz: