Human Polyomaviruses: The Battle of Large and Small Tumor Antigens.

Autor:	Baez CF; Department of Preventive Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Brandão Varella R; Biomedical Institute, Universidade Federal Fluminense, Niterói, Brazil., Villani S; Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milano, Italy., Delbue S; Department of Biomedical, Surgical and Dental Sciences, University of Milano, Milano, Italy.
Jazyk:	angličtina
Zdroj:	Virology : research and treatment [Virology (Auckl)] 2017 Dec 05; Vol. 8, pp. 1178122X17744785. Date of Electronic Publication: 2017 Dec 05 (Print Publication: 2017).
DOI:	10.1177/1178122X17744785
Abstrakt:	About 40 years ago, the large and small tumor antigens (LT-Ag and sT-Ag) of the polyomavirus (PyVs) simian vacuolating virus 40 have been identified and characterized. To date, it is well known that all the discovered human PyVs (HPyVs) encode these 2 multifunctional and tumorigenic proteins, expressed at viral replication early stage. The 2 T-Ags are able to transform cells both in vitro and in vivo and seem to play a distinct role in the pathogenesis of some tumors in humans. In addition, they are involved in viral DNA replication, transcription, and virion assembly. This short review focuses on the structural and functional features of the HPyVs' LT-Ag and sT-Ag, with special attention to their transforming properties. Competing Interests: Declaration of conflicting interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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