Weakness acquired in the intensive care unit. Incidence, risk factors and their association with inspiratory weakness. Observational cohort study.

Autor: Diaz Ballve LP; Hospital Nacional Profesor Alejandro Posadas - Buenos Aires, Argentina.; Universidad Nacional de la Matanza - Buenos Aires, Argentina., Dargains N; Hospital Nacional Profesor Alejandro Posadas - Buenos Aires, Argentina., Urrutia Inchaustegui JG; Hospital Nacional Profesor Alejandro Posadas - Buenos Aires, Argentina.; Clínica Olivos - SMG - Olivos, Buenos Aires, Argentina., Bratos A; Hospital Nacional Profesor Alejandro Posadas - Buenos Aires, Argentina., Milagros Percaz M; Hospital Nacional Profesor Alejandro Posadas - Buenos Aires, Argentina., Bueno Ardariz C; Hospital Nacional Profesor Alejandro Posadas - Buenos Aires, Argentina., Cagide S; Hospital Nacional Profesor Alejandro Posadas - Buenos Aires, Argentina., Balestrieri C; Hospital Nacional Profesor Alejandro Posadas - Buenos Aires, Argentina., Gamarra C; Hospital Nacional Profesor Alejandro Posadas - Buenos Aires, Argentina., Paz D; Hospital Nacional Profesor Alejandro Posadas - Buenos Aires, Argentina., Rotela E; Hospital Nacional Profesor Alejandro Posadas - Buenos Aires, Argentina., Muller S; Hospital Nacional Profesor Alejandro Posadas - Buenos Aires, Argentina., Bustos F; Hospital Nacional Profesor Alejandro Posadas - Buenos Aires, Argentina., Aranda Castro R; Hospital Nacional Profesor Alejandro Posadas - Buenos Aires, Argentina., Settembrino E; Hospital Nacional Profesor Alejandro Posadas - Buenos Aires, Argentina.
Jazyk: English; Spanish; Castilian
Zdroj: Revista Brasileira de terapia intensiva [Rev Bras Ter Intensiva] 2017 Oct-Dec; Vol. 29 (4), pp. 466-475. Date of Electronic Publication: 2017 Dec 07.
DOI: 10.5935/0103-507X.20170063
Abstrakt: Objective: This paper sought to determine the accumulated incidence and analyze the risk factors associated with the development of weakness acquired in the intensive care unit and its relationship to inspiratory weakness.
Methods: We conducted a prospective cohort study at a single center, multipurpose medical-surgical intensive care unit. We included adult patients who required mechanical ventilation ≥ 24 hours between July 2014 and January 2016. No interventions were performed. Demographic data, clinical diagnoses, the factors related to the development of intensive care unit -acquired weakness, and maximal inspiratory pressure were recorded.
Results: Of the 111 patients included, 66 developed intensive care unit -acquired weakness, with a cumulative incidence of 40.5% over 18 months. The group with intensive care unit-acquired weakness were older (55.9 ± 17.6 versus 45.8 ± 16.7), required more mechanical ventilation (7 [4 - 10] days versus 4 [2 - 7.3] days), and spent more time in the intensive care unit (15.5 [9.2 - 22.8] days versus 9 [6 - 14] days). More patients presented with delirium (68% versus 39%), hyperglycemia > 3 days (84% versus 59%), and positive balance > 3 days (73.3% versus 37%). All comparisons were significant at p < 0.05. A multiple logistic regression identified age, hyperglycemia ≥ 3 days, delirium, and mechanical ventilation > 5 days as independent predictors of intensive care unit-acquired weakness. Low maximal inspiratory pressure was associated with intensive care unit-acquired weakness (p < 0.001), and the maximum inspiratory pressure cut-off value of < 36cmH2O had sensitivity and specificity values of 31.8% and 95.5%, respectively, when classifying patients with intensive care unit-acquired weakness.
Conclusion: The intensive care unit acquired weakness is a condition with a high incidence in our environment. The development of intensive care unit-acquired weakness was associated with age, delirium, hyperglycemia, and mechanical ventilation > 5 days. The maximum inspiratory pressure value of ≥ 36cmH2O was associated with a high diagnostic value to exclude the presence of intensive care unit -acquired weakness.
Databáze: MEDLINE
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