Measures of subclinical cardiac dysfunction and increased filling pressures associate with pulmonary arterial pressure in the general population: results from the population-based Rotterdam Study.

Autor: Billar RJ; Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands., Leening MJG; Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands. m.leening@erasmusmc.nl.; Department of Cardiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands. m.leening@erasmusmc.nl.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. m.leening@erasmusmc.nl., Merkus D; Department of Cardiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands., Brusselle GGO; Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.; Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium., Hofman A; Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Stricker BHC; Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands.; Inspectorate for Health Care, Utrecht, The Netherlands., Ghofrani HA; Medizinische Klinik II, University of Giessen and Marburg Lung Center (UGMLC) - Member of the German Center for Lung Research (DZL), Giessen, Germany., Franco OH; Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands., Gall H; Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.; Medizinische Klinik II, University of Giessen and Marburg Lung Center (UGMLC) - Member of the German Center for Lung Research (DZL), Giessen, Germany., Felix JF; Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.
Jazyk: angličtina
Zdroj: European journal of epidemiology [Eur J Epidemiol] 2018 Apr; Vol. 33 (4), pp. 403-413. Date of Electronic Publication: 2017 Dec 13.
DOI: 10.1007/s10654-017-0341-0
Abstrakt: Pulmonary hypertension is associated with increased mortality and morbidity in the elderly population. Heart failure is a common cause of pulmonary hypertension. Yet, the relation between left heart parameters reflective of subclinical cardiac dysfunction and increased filling pressures, and pulmonary arterial pressures in the elderly population remains elusive. Within the population-based Rotterdam Study, 2592 unselected participants with a mean age of 72.6 years (61.4% women) had complete echocardiography data available. We studied the cross-sectional associations of left heart structure and systolic and diastolic function with echocardiographically measured pulmonary artery systolic pressure. Mean pulmonary artery systolic pressure was 25.4 mmHg. After multivariable-adjustment measures of both structure and function were independently associated with pulmonary artery systolic pressure: E/A ratio [0.63 mmHg (95% CI 0.35-0.91) per 1-SD increase], left atrial diameter [0.79 mmHg (0.50-1.09) per 1-SD increase], E/E' ratio [1.27 mmHg (0.92-1.61) per 1-SD increase], left ventricular volume [0.62 mmHg (0.25-0.98) per 1-SD increase], fractional shortening [0.45 mmHg (0.17-0.74) per 1-SD increase], aortic root diameter [- 0.43 mmHg (- 0.72 to - 0.14) per 1-SD increase], mitral valve deceleration time [- 0.31 mmHg (- 0.57 to - 0.05) per 1-SD increase], and E' [1.04 mmHg (0.66-1.42) per 1-SD increase]. Results did not materially differ when restricting the analyses to participants free of symptoms of shortness of breath. Structural and functional echocardiographic parameters of subclinical cardiac dysfunction and increased filling pressures are associated with pulmonary arterial pressures in the unselected general ageing population.
Databáze: MEDLINE
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