Body size modifies the relationship between maternal serum 25-hydroxyvitamin D concentrations and gestational diabetes in high-risk women.

Autor: Valkama AJ; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Tukholmankatu 8 B, P.O. Box 20, 00014, Helsinki, Finland. anita.valkama@helsinki.fi.; Folkhälsan Research Center, University of Helsinki, Tukholmankatu 8 B, P.O. Box 20, 00014, Helsinki, Finland. anita.valkama@helsinki.fi., Meinilä JM; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Tukholmankatu 8 B, P.O. Box 20, 00014, Helsinki, Finland., Koivusalo SB; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Sofianlehdonkatu 5A, P.O. Box 610, 00029, Helsinki, Finland., Lindström J; Department of Chronic Disease Prevention, National Institute for Health and Welfare, Mannerheimintie 166, P.O. Box 30, 00271, Helsinki, Finland., Rönö K; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Sofianlehdonkatu 5A, P.O. Box 610, 00029, Helsinki, Finland., Tiitinen AE; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Sofianlehdonkatu 5A, P.O. Box 610, 00029, Helsinki, Finland., Stach-Lempinen B; Department of Obstetrics and Gynecology, South Karelia Central Hospital, Valto Käkelän katu 3, 53130, Lappeenranta, Finland., Kautiainen HJ; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Tukholmankatu 8 B, P.O. Box 20, 00014, Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Eastern Finland, Yliopistonranta 1, P.O. Box 1627, 70211, Kuopio, Finland., Viljakainen H; Folkhälsan Research Center, University of Helsinki, Tukholmankatu 8 B, P.O. Box 20, 00014, Helsinki, Finland.; Children's Hospital, University of Helsinki and Helsinki University Hospital, Stenbäckinkatu 11, P.O. Box 281, 00029, Helsinki, Finland., Andersson S; Children's Hospital, University of Helsinki and Helsinki University Hospital, Stenbäckinkatu 11, P.O. Box 281, 00029, Helsinki, Finland., Eriksson JG; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Tukholmankatu 8 B, P.O. Box 20, 00014, Helsinki, Finland.; Folkhälsan Research Center, University of Helsinki, Tukholmankatu 8 B, P.O. Box 20, 00014, Helsinki, Finland.; Department of Chronic Disease Prevention, National Institute for Health and Welfare, Mannerheimintie 166, P.O. Box 30, 00271, Helsinki, Finland.
Jazyk: angličtina
Zdroj: European journal of clinical nutrition [Eur J Clin Nutr] 2018 Mar; Vol. 72 (3), pp. 460-463. Date of Electronic Publication: 2017 Nov 06.
DOI: 10.1038/s41430-017-0010-0
Abstrakt: Obesity increases the risk of low 25-hydroxyvitamin D (25(OH)D) concentrations and gestational diabetes (GDM). We explored whether the association between GDM and change in 25(OH)D concentrations measured in the first (7-18 wk) and second (20-27 wk) trimesters of pregnancy is dependent on maternal BMI. The study was a prospective study of 219 women with BMI of ≥30 kg/m 2 , a history of GDM, or both. The participants were stratified by first-trimester BMI: BMI of <25.0, 25.0-29.9, 30.0-34.9, and ≥35 kg/m 2 . In the BMI group ≥35 kg/m 2 , those who did not develop GDM during the follow-up showed higher increase in serum 25(OH)D concentrations compared with women who developed GDM (43.2 vs. 11.5%; P < 0.001). No associations between 25(OH)D concentrations and GDM were observed in other BMI groups. These findings give an important aspect of the role of maternal body size in the association between vitamin D and GDM in high-risk women.
Databáze: MEDLINE
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