Retrospective review of pediatric status epilepticus in 116 Saudi patients: predictors of outcome.

Autor:	Hommady RH, Alrifai MT; Dr. Muhammad Talal Alrifai, Department of Pediatrics Neurology,, King Abdulaziz Medical City,, King Abdullah Specialized Children's Hospital,, Riyadh, Saudi Arabia, T: +966506404163, mtalrif@gmail.com, ORCID ID: https://orcid.org/0000-0002-5203-438X., Mubayrik OK, Alayed RS, Alsemari MA, Arumayyan A, Altuwaijri W, Baarmah D
Jazyk:	angličtina
Zdroj:	Annals of Saudi medicine [Ann Saudi Med] 2017 Nov-Dec; Vol. 37 (6), pp. 455-460.
DOI:	10.5144/0256-4947.2017.455
Abstrakt:	Background: Status epilepticus (SE) is a common, life-threatening condition. Multiple factors are used to predict its outcome and evaluate its risks, and there have been only a few studies in Saudi Arabia. Objectives: Investigate predictors of SE outcome. Design: Retrospective chart review study. Setting: Tertiary center, Riyadh. Patients and Methods: We reviewed all pediatric cases (age 14 years or younger) of SE admitted between January 2005 and December 2015, collecting data on age, sex, date of birth, developmental status, pre-existing neurological diseases, SE etiology, Glasgow Outcome Scale (GOS) scores, and electroencephalogram (EEG) findings. The outcome was categorized as poor based on any decrease in baseline GOS score or moderate-to-severe developmental delay in young children; otherwise outcome was considered good. Main Outcome Measure: Outcome of SE. Results: One hundred and sixteen patients (54% boys) with ages from 1 month to 10 years were included in the analysis. Fifty-five (47.4%) had a poor outcome. The overall mortality rate related to SE was 2.6%. Four patients had an SE duration of more than 24 hours. Univariate and multivariate analysis revealed that poor outcome was related to symptomatic SE etiology and a history of epilepsy. Age, sex, SE duration, and EEG findings were not predictors of poor outcome. Conclusion: Pediatric status epilepticus is highly associated with neurological morbidity. The main pre.dictor of outcome is underlying symptomatic etiology of SE and to a lesser degree the presence of a history of epilepsy. Duration does not seem to play a major role. Limitations: The main limitation is the retrospective chart review nature of the study with possible bias.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu