Autophagy Inhibition in Pancreatic Adenocarcinoma.

Autor: Boone BA; Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA., Zeh HJ 3rd; Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA., Bahary N; Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA. Electronic address: baharyn@upmc.edu.
Jazyk: angličtina
Zdroj: Clinical colorectal cancer [Clin Colorectal Cancer] 2018 Mar; Vol. 17 (1), pp. 25-31. Date of Electronic Publication: 2017 Oct 28.
DOI: 10.1016/j.clcc.2017.10.013
Abstrakt: Although some progress has been made in recent years with the development of more effective chemotherapy regimens, new treatment approaches are needed to improve outcomes for patients with pancreatic adenocarcinoma. The cellular process of autophagy, a cell survival mechanism that allows cancer cells to survive the hazardous conditions of the tumor microenvironment and treatment, has emerged as a viable target in pancreatic cancer. We review the mechanism of autophagy, its role in pancreatic carcinogenesis, the preclinical and clinical evidence supporting targeting autophagy in patients with pancreatic adenocarcinoma, and areas of future investigation that hold promise for improving this treatment approach.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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