The small molecule CLP257 does not modify activity of the K + -Cl - co-transporter KCC2 but does potentiate GABA A receptor activity.

Autor: Cardarelli RA; AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, USA., Jones K; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Alderley Park, UK., Pisella LI; INMED, INSERM, Unité 901, Marseille, France.; Aix-Marseille Université, UMR 901, Marseille, France., Wobst HJ; AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, USA.; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA., McWilliams LJ; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, UK., Sharpe PM; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Alderley Park, UK., Burnham MP; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Alderley Park, UK., Baker DJ; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, UK., Chudotvorova I; INMED, INSERM, Unité 901, Marseille, France.; Aix-Marseille Université, UMR 901, Marseille, France., Guyot J; INMED, INSERM, Unité 901, Marseille, France.; Aix-Marseille Université, UMR 901, Marseille, France., Silayeva L; AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, USA., Morrow DH; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA., Dekker N; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden., Zicha S; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA., Davies PA; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA., Holenz J; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA., Duggan ME; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA., Dunlop J; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA., Mather RJ; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA., Wang Q; AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, USA.; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA., Medina I; INMED, INSERM, Unité 901, Marseille, France.; Aix-Marseille Université, UMR 901, Marseille, France., Brandon NJ; AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, USA.; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA., Deeb TZ; AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, USA., Moss SJ; AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, USA.; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA.; Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
Jazyk: angličtina
Zdroj: Nature medicine [Nat Med] 2017 Dec 07; Vol. 23 (12), pp. 1394-1396.
DOI: 10.1038/nm.4442
Databáze: MEDLINE