Neuropsychological and quality of life assessment in patients with Parkinson's disease submitted to bilateral deep brain stimulation in the subthalamic nucleus.

Autor:	Heluani AS; Psychologist, Department of Psychology of Hospital 'Euriclydes de Jesus Zerbini', São Paulo SP, Brazil., Porto FHG; MD, Neurologist. Behavioral and Cognitive Neurology Unit, Department of Neurology, and Cognitive Disorders Reference Center (CEREDIC). Hospital das Clínicas of the University of São Paulo. Department of Neurosurgery of Hospital 'Euriclydes de Jesus Zerbini', São Paulo SP, Brazil., Listik S; MD, Neurosurgeon. Department of Neurosurgery of Hospital 'Euriclydes de Jesus Zerbini', São Paulo SP, Brazil. Movement Disorders Unit., de Campos AW; MD, Neurosurgeon. Department of Neurosurgery of Hospital 'Euriclydes de Jesus Zerbini', São Paulo SP, Brazil. Movement Disorders Unit., Machado AAC; MD, PhD. Neurologist Department of Neurology, Universidade de São Paulo, São Paulo SP, Brazil., Cukiert A; MD, PhD. Hospital Albert Einstein, São Paulo SP, Brazil., de Oliveira JO Jr; MD, Neurosurgeon in Chief-Movement Disorders Unit - Department of Neurosurgery of Hospital 'Euriclydes de Jesus Zerbini', São Paulo SP, Brazil.
Jazyk:	angličtina
Zdroj:	Dementia & neuropsychologia [Dement Neuropsychol] 2012 Oct-Dec; Vol. 6 (4), pp. 260-265.
DOI:	10.1590/S1980-57642012DN06040010
Abstrakt:	Deep brain stimulation (DBS) has been widely used to control motor symptoms and improve quality of life in patients with Parkinsons disease (PD). Recently, DBS in the subthalamic nucleus (STN) has become the preferred target for patients with mixed motor symptoms. Despite resultant motor and quality of life improvements, the procedure has been associated with cognitive decline, mainly in language skills, and also with psychiatric symptoms. Objective: To evaluate the influence of DBS in the STN on cognition, mood and quality of life. Methods: We studied 20 patients with PD submitted to DBS in the STN from May 2008 to June 2012 with an extensive battery of cognitive tests including memory, language, praxis, executive functions and attention assessments; the Parkinson's Disease Quality of Life Questionnaire (PDQ-39); and the Hospital Anxiety and Depression Scale (HAD), were applied both before and after the surgery. Data was analyzed using SPSS version 17.0 and results compared using the paired Student's t test. Results: A total of 20 patients with pre and post-operative assessments were included. A statistically significant improvement was found in total score and on subscales of mobility, activities of daily living and emotional well-being from the PDQ-39 (P=0.009, 0.025, 0.001 and 0.034, respectively). No significant difference was found on the cognitive battery or mood scale. Conclusion: DBS in the SNT improved quality of life in PD with no negative impact on cognitive skills and mood. Competing Interests: Disclosure: The authors report no conflicts of interest.
Databáze:	MEDLINE
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