Which factors are associated with global cognitive impairment in Wilson's disease?

Autor:	Frota NAF; MD, PhD. School of Medicine, University of Fortaleza, Fortaleza, CE, Brazil. MD, PhD., Barbosa ER; Department of Neurology, University of São Paulo School of Medicine, São Paulo, SP, Brazil., Porto CS; PhD. Department of Neurology, University of São Paulo School of Medicine, São Paulo, SP Brazil., Lucato LT; MD, PhD. Department of Radiology, University of São Paulo School of Medicine, São Paulo, SP, Brazil., Ono CR; MD, PhD. Department of Radiology, University of São Paulo School of Medicine, São Paulo, SP, Brazil., Buchpiguel CA; MD, PhD. Department of Radiology, University of São Paulo School of Medicine, São Paulo, SP, Brazil., Machado AAC; Department of Neurology, University of São Paulo School of Medicine, São Paulo, SP, Brazil., Caramelli P; MD, PhD. Department of Internal Medicine, Faculty of Medicine, Federal University of Minas Gerais, MG, Brazil.
Jazyk:	angličtina
Zdroj:	Dementia & neuropsychologia [Dement Neuropsychol] 2016 Oct-Dec; Vol. 10 (4), pp. 320-326.
DOI:	10.1590/s1980-5764-2016dn1004011
Abstrakt:	Background: Patients with Wilson's disease (WD) present cognitive impairment, especially in executive functions. Which other factors might be associated with global cognitive decline in these patients remains unclear. Objective: To assess which factors are associated with worse performance on a global cognitive test in patients with WD. Methods: Twenty patients with WD underwent cognitive assessment with the following tests: the Mini-Mental State Examination (MMSE), Dementia Rating Scale (DRS), verbal fluency test, brief cognitive battery, clock drawing test, Frontal Assessment Battery, Stroop test, Wisconsin card sorting test, Hopper test, cubes (WAIS) and the Pfeffer questionnaire. MRI changes were quantified. Patients with poor performance on the DRS were compared to patients with normal performance. Results: Nine patients had a poor performance on the DRS. This group had lower educational level (9.11±3.58× 12.82±3.06) and a greater number of changes on MRI (9.44±2.74× 6.27±2.45). The presence of hyperintensity in the globus pallidus on MRI was more frequent in this group (66.6% vs 9.0%), with OR=5.38 (95% CI 0.85-33.86). Conclusion: Global cognitive impairment was prevalent in this sample of patients with WD and was associated with low educational level, number of changes on MRI and MRI hyperintensity in the globus pallidus. Competing Interests: Disclosure: The authors report no conflicts of interest.
Databáze:	MEDLINE
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