Self-sampling for human papillomavirus testing among rural young women of KwaZulu-Natal, South Africa.

Autor:	Mbatha JN; School Laboratory Medicine and Medical Science, University of KwaZulu-Natal, Durban, South Africa. nonhlanhlam@dut.ac.za.; Department of Biomedical and Clinical Technology, Durban University of Technology, PO Box 1334, Durban, 4000, South Africa. nonhlanhlam@dut.ac.za., Galappaththi-Arachchige HN; Norwegian Centre for Imported and Tropical Diseases, Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, University of Oslo, Oslo, Norway., Mtshali A; School Laboratory Medicine and Medical Science, University of KwaZulu-Natal, Durban, South Africa., Taylor M; Discipline of Public Health, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa., Ndhlovu PD; Claybrook Center, Imperial College London, London, UK., Kjetland EF; Norwegian Centre for Imported and Tropical Diseases, Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway.; Discipline of Public Health, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa., Baay MFD; Norwegian Centre for Imported and Tropical Diseases, Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway.; Laboratory of Cancer Research and Clinical Oncology, University of Antwerp, Antwerp, Belgium., Mkhize-Kwitshana ZL; School Laboratory Medicine and Medical Science, University of KwaZulu-Natal, Durban, South Africa.; Department of Biomedical Sciences, Mangosuthu University of Technology, Durban, South Africa.
Jazyk:	angličtina
Zdroj:	BMC research notes [BMC Res Notes] 2017 Dec 06; Vol. 10 (1), pp. 702. Date of Electronic Publication: 2017 Dec 06.
DOI:	10.1186/s13104-017-3045-3
Abstrakt:	Background: Cervical cancer is a major problem in women and it is important to find a suitable and acceptable screening method, especially among young in low-resource areas for future human papillomavirus (HPV) vaccine follow-up investigations. The study sought to test the acceptability of self-sampling as well as the suitability of the specimen collecting devices. Methods: Ninety-eight young women from rural KwaZulu-Natal were enrolled between March and July 2014. Collected genital specimens were transferred to colour indicator cards for HPV detection. Participants answered a questionnaire where they described their experiences with self-sampling. Samples were tested for high-risk HPV using GP5/6+ PCR. Results: Of the enrolled participants, 91 answered questionnaires and indicated that self-sampling was preferred by 51/91 (56%) women while 40/91 (44%) indicated preference for sampling by a doctor (p = 0.023). The majority, 64% were comfortable using a swab, 22% preferred a brush while 11% were comfortable with both devices. Of the 98 self-sampled specimens 61 were negative for HPV in both specimens while 37 were HPV-positive in either brush or swab. Of the 37, 26 (70%) were HPV-positive in both brush and swab (kappa = 0.743) and 11 (30%) were discordant. Conclusions: Self-sampling was acceptable to the majority of participants in this rural area. The Dacron swab was the preferred device, and can be used in combination with colour indicator cards for comfortable self-sampling, easy storage and transport of specimens plus detection.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu PDF