Association study of methylenetetrahydrofolate reductase genetic polymorphism 677C>T with schizophrenia in hospitalized patients in population of European Russia.

Autor: Zhilyaeva TV; Russia. Electronic address: bizet@inbox.ru., Sergeeva AV; Research Institute of Preventive Medicine, Nizhny Novgorod State Medical Academy, 10/1 Minina and Pozharskogo sq., Nizhny Novgorod, 603005, Russia. Electronic address: sergeeva-av2013@yandex.ru., Blagonravova AS; Research Institute of Preventive Medicine, Nizhny Novgorod State Medical Academy, 10/1 Minina and Pozharskogo sq., Nizhny Novgorod, 603005, Russia. Electronic address: a.blagonravova@mail.ru., Kasimova LN; Russia. Electronic address: kasimovaln@inbox.ru., Kuznetsov KV; N.Ya. Klimova Nizhny Novgorod Regional Blood Center(1), 194 Rodionova st., Nizhny Novgorod, 603950, Russia., Golovanova VI; N.Ya. Klimova Nizhny Novgorod Regional Blood Center(1), 194 Rodionova st., Nizhny Novgorod, 603950, Russia., Shebolkova TB; N.Ya. Klimova Nizhny Novgorod Regional Blood Center(1), 194 Rodionova st., Nizhny Novgorod, 603950, Russia., Korshunova EA; N.Ya. Klimova Nizhny Novgorod Regional Blood Center(1), 194 Rodionova st., Nizhny Novgorod, 603950, Russia.
Jazyk: angličtina
Zdroj: Asian journal of psychiatry [Asian J Psychiatr] 2018 Feb; Vol. 32, pp. 29-33. Date of Electronic Publication: 2017 Nov 29.
DOI: 10.1016/j.ajp.2017.11.027
Abstrakt: The purpose of the research was to investigate the association of methylenetetrahydrofolate reductase (hereinafter MTHFR) genetic polymorphism 677C>T with schizophrenia in the Russian population in comparison with the control group of healthy blood donors. Also some characteristics of schizophrenia were examined in patients with/without defective T-allele of MTHFR677C>T polymorphism. 500 patients with schizophrenia and 499 blood donors were examined for T-allele carriage of polymorphism MTHFR677C>T by PCR method. 150 archival medical records were studied (in the first patients included in the study). The carriage of T-allele of genetic polymorphism MTHFR677C>T was significantly more common in patients than in healthy donors: 255/500 versus 219/499 (p=0,0287, χ2=4,79; OR=1,33, 95%CI [1037; 1707]). The number of patients with chronic type of schizophrenia onset was significantly more among T-allele carriers (n=77) than among normal CC-genotype carriers (n=73): р=0.038. The number of "incapacitated" persons in the group of patients with defective T-allele (n=77) was significantly higher than in patients with normal genotype (n=73, p=0.0439; OR=2.878, 95%CI=1.111-7.456). The results suggest that T-allele of genetic polymorphism MTHFR677C>T in the population of European Russia may increase the risk of developing schizophrenia and its unfavorable prognosis, which requires further investigation.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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