Correlation between interferon γ and interleukin 6 with PTSD and resilience.

Autor: Bruenig D; Institute of Health and Biomedical Innovation (IHBI) and School of Biomedical Sciences, 60 Musk Avenue, Queensland University of Technology, Kelvin Grove, Queensland 4059, Australia; Gallipoli Medical Research Institute, Greenslopes Private Hospital, Newdegate Street, Greenslopes, Queensland 4120, Australia., Mehta D; Institute of Health and Biomedical Innovation (IHBI) and School of Psychological and Counselling, 60 Musk Avenue, Queensland University of Technology, Kelvin Grove, Queensland 4059, Australia., Morris CP; Institute of Health and Biomedical Innovation (IHBI) and School of Biomedical Sciences, 60 Musk Avenue, Queensland University of Technology, Kelvin Grove, Queensland 4059, Australia., Lawford B; Institute of Health and Biomedical Innovation (IHBI) and School of Biomedical Sciences, 60 Musk Avenue, Queensland University of Technology, Kelvin Grove, Queensland 4059, Australia., Harvey W; Gallipoli Medical Research Institute, Greenslopes Private Hospital, Newdegate Street, Greenslopes, Queensland 4120, Australia., McD Young R; Institute of Health and Biomedical Innovation (IHBI) and School of Psychological and Counselling, 60 Musk Avenue, Queensland University of Technology, Kelvin Grove, Queensland 4059, Australia., Voisey J; Institute of Health and Biomedical Innovation (IHBI) and School of Biomedical Sciences, 60 Musk Avenue, Queensland University of Technology, Kelvin Grove, Queensland 4059, Australia. Electronic address: j.voisey@qut.edu.au.
Jazyk: angličtina
Zdroj: Psychiatry research [Psychiatry Res] 2018 Feb; Vol. 260, pp. 193-198. Date of Electronic Publication: 2017 Nov 28.
DOI: 10.1016/j.psychres.2017.11.069
Abstrakt: Posttraumatic Stress Disorder (PTSD) is a debilitating psychiatric disorder with decreased general health prognosis and increased mortality. Inflammation has been hypothesised to be a link between PTSD and the most common co-morbid medical disorders. However, the relationship between inflammation and PTSD is not clear. Individual inflammatory markers have shown variable associations with PTSD. This study investigates the correlations between serum cytokines, PTSD and resilience in a cohort of Caucasian Vietnam combat veterans (n = 299). After correction for multiple testing, PTSD severity was correlated with small but significant decreases in interleukin 6 and interferon γ (p = 0.004, p = 0.013, respectively) whereas resilience was correlated with increased levels of interleukin 6 and interferon γ (p = 0.023; p = 0.007, respectively). Analyses of sub-symptoms of PTSD revealed that mood and arousal symptoms showed the most significant effect on interleukin 6 and interferon γ. More research is needed to further elucidate the mechanisms underlying the relationship between cytokine levels, PTSD sub-symptoms and trauma outcomes to improve the knowledge base of differences in trauma response and the biological system.
(Crown Copyright © 2017. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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