Comparison between FEV 1 /FEV 6 and FEV 1 /FVC as screening of chronic obstructive pulmonary disease.

Autor: Ng SC; Hospital Tuanku Fauziah, Medical Department, Jalan Kolam, Kangar, Perlis Indera Kayangan, Malaysia. xuiayushiching@gmail.com., Abu Samah F; Hospital Tuanku Fauziah, Medical Department, Jalan Kolam, Kangar, Perlis Indera Kayangan, Malaysia., Helmy K; Hospital Tuanku Fauziah, Medical Department, Jalan Kolam, Kangar, Perlis Indera Kayangan, Malaysia., Sia KK; Hospital Tuanku Fauziah, Medical Department, Jalan Kolam, Kangar, Perlis Indera Kayangan, Malaysia.
Jazyk: angličtina
Zdroj: The Medical journal of Malaysia [Med J Malaysia] 2017 Oct; Vol. 72 (5), pp. 286-290.
Abstrakt: Objective: To compare FEV 1 /FEV 6 to the standard spirometry (FEV 1 /FVC) as a screening tool for COPD.
Methods: This cross-sectional study was conducted at Hospital Tuanku Fauziah, Perlis, Malaysia from August 2015 to April 2016. FEV 1 /FEV 6 and FEV 1 /FVC results of 117 subjects were analysed. Demographic data and spirometric variables were tabulated. A scatter plot graph with Spearman's correlation was constructed for the correlation between FEV 1 /FEV 6 and FEV1/FVC. The sensitivity, specificity, positive and negative predictive values of FEV 1 /FEV 6 were determined with reference to the gold standard of FEV 1 /FVC ratio <0.70. Receiver-operator characteristic (ROC) curve analysis and Kappa statistics were used to determine the FEV 1 /FEV 6 ratio in predicting an FEV 1 /FVC ratio <0.70.
Results: Spearman's correlation with r = 0.636 (P<0.001) was demonstrated. The area under the ROC curve was 0.862 (95% confidence interval [CI]: 0.779 - 0.944, P<0.001). The FEV 1 /FEV 6 cut-off with the greatest sum of sensitivity and specificity was 0.75. FEV 1 /FEV 6 sensitivity, specificity, positive and negative predictive values were 93.02%, 67.74%, 88.89% and 77.78% respectively. There was substantial agreement between the two diagnostic cut-offs (κ = 0.634; 95% CI: 0.471 - 0.797, P<0.001) CONCLUSIONS: The FEV 1 /FEV 6 ratio can be considered to be a good alternative to the FEV 1 /FVC ratio for screening of COPD. Larger multicentre study and better education on spirometric techniques can validate similar study outcome and establish reference values appropriate to the population being studied.
Databáze: MEDLINE
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