The national burden of influenza-associated severe acute respiratory illness hospitalization in Rwanda, 2012-2014.

Autor: Nyamusore J; Epidemic Surveillance and Response Division, Rwanda Biomedical Center, Ministry of Health, Kigali, Rwanda., Rukelibuga J; Influenza Program, Centers for Disease Control and Prevention, Kigali, Rwanda., Mutagoma M; Epidemic Surveillance and Response Division, Rwanda Biomedical Center, Ministry of Health, Kigali, Rwanda., Muhire A; Health Management Information System Division, Ministry of Health, Kigali, Rwanda., Kabanda A; National Reference Laboratory, Rwanda Biomedical Center, Ministry of Health, Kigali, Rwanda., Williams T; Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA., Mutoni A; Epidemic Surveillance and Response Division, Rwanda Biomedical Center, Ministry of Health, Kigali, Rwanda., Kamwesiga J; Epidemic Surveillance and Response Division, Rwanda Biomedical Center, Ministry of Health, Kigali, Rwanda., Nyatanyi T; Epidemic Surveillance and Response Division, Rwanda Biomedical Center, Ministry of Health, Kigali, Rwanda., Omolo J; Influenza Program, Centers for Disease Control and Prevention, Kigali, Rwanda., Kabeja A; Epidemic Surveillance and Response Division, Rwanda Biomedical Center, Ministry of Health, Kigali, Rwanda., Koama JB; Influenza Program, Centers for Disease Control and Prevention, Kigali, Rwanda., Mukarurangwa A; National Reference Laboratory, Rwanda Biomedical Center, Ministry of Health, Kigali, Rwanda., Umuringa JD; National Reference Laboratory, Rwanda Biomedical Center, Ministry of Health, Kigali, Rwanda., Granados C; Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA., Gasana M; Institute of HIV/AIDS, Disease Prevention and Control, Rwanda Biomedical Center, Ministry of Health, Kigali, Rwanda., Moen A; Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA., Tempia S; Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA.; Influenza Program, Centers for Disease Control and Prevention, Pretoria, South Africa.; Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.
Jazyk: angličtina
Zdroj: Influenza and other respiratory viruses [Influenza Other Respir Viruses] 2018 Jan; Vol. 12 (1), pp. 38-45. Date of Electronic Publication: 2017 Dec 02.
DOI: 10.1111/irv.12494
Abstrakt: Background: Estimates of influenza-associated hospitalization are severely limited in low- and middle-income countries, especially in Africa.
Objectives: To estimate the national number of influenza-associated severe acute respiratory illness (SARI) hospitalization in Rwanda.
Methods: We multiplied the influenza virus detection rate from influenza surveillance conducted at 6 sentinel hospitals by the national number of respiratory hospitalization obtained from passive surveillance after adjusting for underreporting and reclassification of any respiratory hospitalizations as SARI during 2012-2014. The population at risk was obtained from projections of the 2012 census. Bootstrapping was used for the calculation of confidence intervals (CI) to account for the uncertainty associated with all levels of adjustment. Rates were expressed per 100 000 population. A sensitivity analysis using a different estimation approach was also conducted.
Results: SARI cases accounted for 70.6% (9759/13 813) of respiratory admissions at selected hospitals: 77.2% (6783/8786) and 59.2% (2976/5028) among individuals aged <5 and ≥5 years, respectively. Overall, among SARI cases tested, the influenza virus detection rate was 6.3% (190/3022): 5.7% (127/2220) and 7.8% (63/802) among individuals aged <5 and ≥5 years, respectively. The estimated mean annual national number of influenza-associated SARI hospitalizations was 3663 (95% CI: 2930-4395-rate: 34.7; 95% CI: 25.4-47.7): 2637 (95% CI: 2110-3164-rate: 168.7; 95% CI: 135.0-202.4) among children aged <5 years and 1026 (95% CI: 821-1231-rate: 11.3; 95% CI: 9.0-13.6) among individuals aged ≥5 years. The estimates obtained from both approaches were not statistically different (overlapping CIs).
Conclusions: The burden of influenza-associated SARI hospitalizations was substantial and was highest among children aged <5 years.
(© 2017 The Authors. Influenza and Other Respiratory Viruses. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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