| Autor: |
Lake BG; British Industrial Biological Research Association (BIBRA), Carshalton, Surrey, U.K., Gray TJ, Körösi SA, Walters DG |
| Jazyk: |
angličtina |
| Zdroj: |
Toxicology letters [Toxicol Lett] 1989 Feb; Vol. 45 (2-3), pp. 221-9. |
| DOI: |
10.1016/0378-4274(89)90013-1 |
| Abstrakt: |
Male Sprague-Dawley rats were given oral doses of nafenopin (80 mg/kg/d) for up to 28 d. Nafenopin administration resulted in liver enlargement and induction of peroxisomal fatty acid beta-oxidation enzymes (which generate hydrogen peroxide), but little effect was observed on catalase and cytosolic GSH peroxidase was decreased. Hepatic vitamin E levels were depleted to around 50% of control. A small increase in hepatic oxidised glutathione (GSSG) content was paralleled in a time-dependent increase in plasma GSSG. These changes in vitamin E and GSSG levels may represent early indicators of oxidative stress produced in rat hepatocytes by nafenopin and other peroxisome proliferators as a consequence of the increased production of hydrogen peroxide. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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