Dynamic and Responsive Growth Factor Delivery from Electrospun and Hydrogel Tissue Engineering Materials.

Autor: Bruggeman KF; Laboratory of Advanced Biomaterials, Research School of Engineering, The Australian National University, Canberra, ACT, 2601, Australia., Williams RJ; School of Engineering, RMIT University, Melbourne, VIC, 3001, Australia.; Biofab3D, Aikenhead Center for Medical Discovery, St. Vincent's Hospital, Melbourne, VIC, 3065, Australia., Nisbet DR; Laboratory of Advanced Biomaterials, Research School of Engineering, The Australian National University, Canberra, ACT, 2601, Australia.; Biofab3D, Aikenhead Center for Medical Discovery, St. Vincent's Hospital, Melbourne, VIC, 3065, Australia.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2018 Jan; Vol. 7 (1). Date of Electronic Publication: 2017 Nov 30.
DOI: 10.1002/adhm.201700836
Abstrakt: Tissue engineering scaffolds are designed to mimic physical, chemical, and biological features of the extracellular matrix, thereby providing a constant support that is crucial to improved regenerative medicine outcomes. Beyond mechanical and structural support, the next generation of these materials must also consider the more dynamic presentation and delivery of drugs or growth factors to guide new and regenerating tissue development. These two aspects are explored expansively separately, but they must interact synergistically to achieve optimal regeneration. This review explores common tissue engineering materials types, electrospun polymers and hydrogels, and strategies used for incorporating drug delivery systems into these scaffolds.
(© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
Externí odkaz: