| Autor: |
Meydanli EG; a Department of Histology & Embryology , Istanbul University Cerrahpasa Medical Faculty , Istanbul , Turkey., Gumusel A; a Department of Histology & Embryology , Istanbul University Cerrahpasa Medical Faculty , Istanbul , Turkey., Ozkan S; a Department of Histology & Embryology , Istanbul University Cerrahpasa Medical Faculty , Istanbul , Turkey., Tanriverdi G; a Department of Histology & Embryology , Istanbul University Cerrahpasa Medical Faculty , Istanbul , Turkey., Balci MBC; b Department of Urology , G.O.P Taksim Training and Research Hospital , Istanbul , Turkey., Develi Is S; c Department of Biochemistry , Istanbul University Istanbul Medical Faculty , Istanbul , Turkey., Hazar AI; b Department of Urology , G.O.P Taksim Training and Research Hospital , Istanbul , Turkey., Uysal M; c Department of Biochemistry , Istanbul University Istanbul Medical Faculty , Istanbul , Turkey., Bekpinar S; c Department of Biochemistry , Istanbul University Istanbul Medical Faculty , Istanbul , Turkey. |
| Abstrakt: |
This study investigated whether a high-fructose (HFr) diet changes the morphology of seminiferous tubules (ST) in rats and resveratrol (RES) has a possible restoring effect in this sense. Fructose (30%; w/v) was administered to rats alone or together with RES (50 mg/L) in drinking water for 8 weeks. In the HFr group, destruction of the germinal epithelium led to the detection of immature germ cells in the lumen. HFr diet gave rise to a decrease in the ST diameters (p < 0.05), Johnsen's tubular biopsy score values (p < 0.001), and an increase in the apoptotic index (p < 0.05). Ultrastructurally, HFr feeding increased lipid accumulation (p < 0.01), mitochondrial damage, and acrosomal abnormalities in spermatogenic cells. Treatment of HFr -fed rats with RES improved the reduced ST diameters and overall general histological and ultrastructural abnormalities of the STs, but did not change the increased apoptotic index. |
