Single shot of 17D vaccine may not confer life-long protection against yellow fever.

Autor: Vasconcelos PF; Instituto Evandro Chagas, Ananindeua, PA, Brasil.
Jazyk: angličtina
Zdroj: Memorias do Instituto Oswaldo Cruz [Mem Inst Oswaldo Cruz] 2018 Feb; Vol. 113 (2), pp. 135-137. Date of Electronic Publication: 2017 Nov 27.
DOI: 10.1590/0074-02760170347
Abstrakt: The yellow fever (YF) vaccine has been used since the 1930s to prevent YF, which is a severe infectious disease caused by the yellow fever virus (YFV), and mainly transmitted by Culicidae mosquitoes from the genera Aedes and Haemagogus . Until 2013, the World Health Organization (WHO) recommended the administration of a vaccine dose every ten years. A new recommendation of a single vaccine dose to confer life-long protection against YFV infection has since been established. Recent evidence published elsewhere suggests that at least a second dose is needed to fully protect against YF disease. Here, we discuss the feasibility of administering multiple doses, the necessity for a new and modern vaccine, and recommend that the WHO conveys a meeting to discuss YFV vaccination strategies for people living in or travelling to endemic areas.
Databáze: MEDLINE